PRESSOR HORMONES IN ELDERLY HYPERTENSIVE PERSONS - RACIAL-DIFFERENCES
PRESSOR HORMONES IN ELDERLY HYPERTENSIVE PERSONS - RACIAL-DIFFERENCES
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DOI：
10.1161/01.hyp.15.2_suppl.i88
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发表时间：
1990-02-01
期刊：
影响因子：
8.3
通讯作者：
GAVRAS, H
中科院分区：
文献类型：
--
作者：
BURSZTYN, M;BRESNAHAN, M;GAVRAS, H
本研究的目的是检测老年非药物自由生活受试者的升压激素和血小板α2-肾上腺素能受体。87例受试者，平均年龄+/-5岁(平均+/-SD)，高血压或正常血压(血压<160/90 mm Hg)，测定血中去甲肾上腺素、肾上腺素和加压素水平，以及血小板膜上α2-肾上腺素能受体的密度和亲和力，以最大结合数(Bmax)和解离常数(Kd)计算。分为白色高血压组(n=22)、正常血压组(n=41)、黑色高血压组(n=11)、正常血压组(n=13)，高血压组与正常血压组年龄分布相似，血压水平相近。黑人高血压组血管加压素水平高于白人高血压组(1.5+/-1.0pg/mlvs.0.7+/-0.5pg/ml，p<0.005)，而肾上腺素与舒张压呈负相关(r=-0.7pg/ml，p<0.02)。白人正常血压组、黑人高血压组和白色高血压组的KD分别为1.6nM+/-0.6nM、1.1nM+/-0.2nM、1.1nM+/-0.3nM，P<0.002。Bmax在不同组之间没有差异，但与整个组的加压素水平显著相关(r=0.40，p<0.0004)，尽管在黑人高血压组中不存在这种相关性。这些数据表明，不同的血管收缩系统在不同程度上参与了老年白人和黑人高血压的产生和持续机制。
The purpose of this study was to examine pressor hormones and platelet alpha 2-adrenergic receptors in elderly unmedicated free-living subjects. Eighty-seven subjects, 70 +/- 5 years old (mean +/- SD), hypertensive or normotensive (blood pressure less than 160/90 mm Hg) were recruited for measurement of blood levels of norepinephrine, epinephrine, and vasopressin, as well as density and affinity of alpha 2-adrenergic receptors from platelet membranes, assessed by maximal binding (Bmax) and dissociation constant (Kd) of rauwolscine. They were separated into white hypertensive (n = 22) or normotensive (n = 41), and black hypertensive (n = 11) or normotensive (n = 13) groups, with similar age distribution throughout and similar blood pressure levels in the hypertensive and normotensive groups. Vasopressin was higher in the black hypertensive than white hypertensive group (1.5 +/- 1.0 vs. 0.7 +/- 0.5 pg/ml, respectively, p less than 0.005), whereas epinephrine correlated inversely with diastolic blood pressure (r = -0.7, p less than 0.02, in the black hypertensive group). Kd was higher in the black normotensive group than in the other groups (1.6 +/- 0.6 vs. 1.0 +/- 0.2, 1.1 +/- 0.3, or 1.0 +/- 0.3 nM in the white normotensive, black hypertensive, or white hypertensive group, respectively, p less than 0.002). Bmax was no different among groups but was significantly correlated with vasopressin levels for the whole group (r = 0.4, p less than 0.0004) although no such correlation existed within the black hypertensive group. The data suggest that various vasoconstrictor systems participate to different extents in the mechanisms generating and sustaining hypertension in elderly white and black subjects.