Donepezil improves the cognitive impairment in a tree shrew model of Alzheimer’s disease induced by amyloid-β1–40 via activating the BDNF/TrkB signal pathway
Donepezil improves the cognitive impairment in a tree shrew model of Alzheimer’s disease induced by amyloid-β1–40 via activating the BDNF/TrkB signal pathway
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多奈哌齐通过激活 BDNF/TrkB 信号通路改善淀粉样蛋白-β1-40 诱导的阿尔茨海默病树鼩模型的认知障碍
DOI：
10.1007/s11011-018-0303-6
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发表时间：
2018-08
影响因子：
3.6
通讯作者：
Jianlin Jiao
中科院分区：
文献类型：
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作者：
Hong Zheng;Shiwei Niu;Hongbin Zhao;Shude Li;Jianlin Jiao
阿尔茨海默病 (AD) 是一种慢性神经退行性疾病，可导致老年人记忆丧失和认知损伤；此外，临床和动物研究的证据表明，AD 总是表现出严重的认知缺陷。何
Alzheimer’s disease (AD) is a chronic neurodegenerative disorder which can contribute to memory loss and cognitive damage in the elderly; moreover, evidence from clinical and animal studies demonstrated that AD always exhibit severe cognitive deficits. Ho