Stem Cell Vitality Assessment Using Magnetic Particle Spectroscopy
Stem Cell Vitality Assessment Using Magnetic Particle Spectroscopy
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DOI：
10.1109/tmag.2014.2337052
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发表时间：
2015-02-01
影响因子：
2.1
通讯作者：
Jakob, Peter Michael
中科院分区：
文献类型：
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作者：
Fidler, Florian;Steinke, Maria;Jakob, Peter Michael
在再生医学领域，我们专注于使用具有愈合能力的适当细胞修复受损组织，如人间充质干细胞（hMSCs）。使用干细胞进行组织愈合只有在细胞能够定位到它们的目标时才有可能。除了细胞在目标器官的归巢，在愈合过程中评估细胞活力是最重要的。为了保证细胞归巢，间充质干细胞必须被标记为长期的、无创的细胞监测。用氧化铁纳米颗粒标记的细胞归巢可以用各种方法跟踪，如磁颗粒成像或磁共振成像。在本文中，我们提出了我们的第一个结果监测细胞活力在体外基于磁粒子光谱的发现。
In the field of regenerative medicine, we focus on repairing damaged tissue using appropriate cells for therapy that have healing capacities, such as human mesenchymal stem cells (hMSCs). Tissue healing using stem cells will only be possible if the cells can be homed to their target. Beside cell homing at the targeted organ, assessing the cell vitality is of paramount interest during the healing process. To guarantee cell homing, hMSCs have to be labeled for long-term, noninvasive cell monitoring. Cell homing of labeled cells with iron oxide nanoparticles can be tracked with various methods like magnetic particle imaging or magnetic resonance imaging. In this paper, we present our first results in monitoring the cell vitality in vitro based on magnetic particle spectroscopy findings.