Expression of a retinoid-inducible tumor suppressor, Tazarotene-inducible gene-3, is decreased in psoriasis and skin cancer.
Expression of a retinoid-inducible tumor suppressor, Tazarotene-inducible gene-3, is decreased in psoriasis and skin cancer.
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发表时间：
2000-08
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通讯作者：
M. Duvic;Bharati S. Helekar;C. Schulz;Mimi Cho;D. Disepio;C. Hager;Dominique DiMao;P. Hazarika;B. Jackson;J. Breuer-Mcham;J. Young;G. Clayman;S. Lippman;Roshandra A S Chandraratna;N. Robinson;A. Deucher;R. Eckert;S. Nagpal
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作者：
M. Duvic;Bharati S. Helekar;C. Schulz;Mimi Cho;D. Disepio;C. Hager;Dominique DiMao;P. Hazarika;B. Jackson;J. Breuer-Mcham;J. Young;G. Clayman;S. Lippman;Roshandra A S Chandraratna;N. Robinson;A. Deucher;R. Eckert;S. Nagpal
Tazarotene-induced gene-3 (TIG-3), isolated from human keratinocytes treated with the retinoic acid receptor-selective retinoid Tazarotene, is homologous to H-rev, a class II tumor suppressor. TIG-3 gene localized to chromosome 11q23, a site of loss of heterozygosity in several malignancies. Retinoids influence epidermal differentiation and are used to treat and prevent skin cancer. Therefore, we studied TIG-3 mRNA expression in psoriasis and in basal and SCCs by in situ hybridization and a quantitative QT-RT-PCR assay. Psoriasis lesions had significantly lower staining (median, 3) than paired normal control skin (median, 4; P = 0.012). TIG-3 mRNA was significantly higher in normal control skin (P = 0.001), in paired adjacent skin (median, 3; P = 0.007), and in overlying epidermis (median, 3.0; P = 0.0001) than in 21 SCC specimens as a group (median, 1.5).
