Recent advances in polyphosphoester and polyphosphoramidate - Based biomaterials
Recent advances in polyphosphoester and polyphosphoramidate - Based biomaterials
复制标题
聚磷酸酯和聚氨基磷酸酯基生物材料的最新进展
DOI：
10.1080/10426500701734620
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发表时间：
2008-02-01
影响因子：
1.3
通讯作者：
Zhuo, Ren-Xi
中科院分区：
文献类型：
--
作者：
Huang, Shi-Wen;Zhuo, Ren-Xi
聚磷酸酯和聚氨基磷酸酯是两类重要的含磷聚合物，由于其在生物医学领域的应用，近年来受到越来越多的关注。聚磷酸酯和聚氨基磷酸酯的生物降解性、生物相容性和结构多样性使其成为可能，从而开发出各种新型的磷酸酯基聚合物用于药物递送、基因递送和组织工程。本文综述了聚磷酸酯和聚磷酰胺基生物材料的合成与表征、降解、生物相容性以及在药物输送、基因输送和神经修复等方面的重要应用。
Polyphosphoesters and polyphosphoramidates are important two classes of phosphorous-containing polymers, which have received more and more attention in the past decade for the application in biomedical field. The unique characteristic of biodegradation, biocompatibility and structure versatility of polyphosphoesters and polyphosphoramidates makes it possible to develop a variety of novel phosphate-based polymers for drug delivery, gene delivery and tissue engineering. In this review, we highlighted the recent advances in polyphosphoester and polyphosphoramidate-based biomaterials including synthesis and characterization, degradation, biocompatibility, and important application in drug delivery, gene delivery and nerve repairing.