Cardiovascular risk factors and atherosclerosis in young males - ARMY study (atherosclerosis risk-factors in male youngsters)
Cardiovascular risk factors and atherosclerosis in young males - ARMY study (atherosclerosis risk-factors in male youngsters)
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DOI：
10.1161/01.cir.0000085996.95532.ff
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发表时间：
2003-09-02
期刊：
影响因子：
37.8
通讯作者：
Wick, G
中科院分区：
文献类型：
--
作者：
Knoflach, M;Kiechl, S;Wick, G
尸检研究表明动脉粥样硬化始于儿童时期，但这一概念在体内的证实是稀疏的，仅限于选定的人群样本。此外，新的动脉粥样硬化的风险概念，重点是炎症，感染和免疫尚未在这个年龄组进行评估。方法和结果，这项研究是在141个17- 18岁的白色男性同质的年龄和性别的样本。除了经典的危险因素，C-反应蛋白和体液和细胞免疫反应热休克蛋白（HSP）进行了评估。在颈动脉和股动脉的4个血管节段处量化内膜中层厚度（IMT）。如果至少1个血管节段的IMT超过第90百分位数，则认为存在高IMT。在多变量logistic回归分析中，吸烟、高舒张压、对人类和/或分枝杆菌HSP 60的显著免疫反应性、饮酒（反向）和低HDL胆固醇水平均与高IMT相关。当单个个体的危险因素从0增加到4时，高IMT的患病率从0增加到60%（P
Background-Necropsy studies suggest that atherosclerosis begins in childhood, but in vivo confirmation of this concept is sparse and limited to selected population samples. Furthermore, new risk concepts of atherosclerosis focusing on inflammation, infections, and immunity have not yet been evaluated in this age group.Methods and Results-This study was conducted in a sample of 141 17- to 18-year-old white males homogenous in age and sex. In addition to classic risk factors, C-reactive protein and the humoral and cellular immune reactivity to heat-shock proteins (HSPs) were assessed. Intima-media thickness (IMT) was quantified at 4 vessel segments of the carotid and femoral arteries. High IMT was considered to be present if the IMT of at least 1 vessel segment exceeded the 90th percentile. In a multivariate logistic regression analysis, cigarette smoking, high diastolic blood pressure, prominent immune reactivity to human and/or mycobacterial HSP60s, alcohol consumption (inverse), and low HDL cholesterol levels were all associated with high IMT. The prevalence of high IMT substantially increased from 0 to 60% when the number of risk conditions in a single individual increased from 0 to 4 (P