Optimal Environmental Stiffness for Stem Cell Mediated Ischemic Myocardium Repair.
Optimal Environmental Stiffness for Stem Cell Mediated Ischemic Myocardium Repair.
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DOI：
10.1007/978-1-4939-6756-8_23
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发表时间：
2017
期刊：
影响因子：
--
通讯作者：
Xu M
中科院分区：
文献类型：
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作者：
Liu H;Paul C;Xu M
与心肌梗死（MI）相关的心血管疾病是全球发病率和死亡率的重要原因。心肌梗死时心肌细胞的丢失是心脏泵功能受损的关键因素。采用细胞移植作为再生缺血心肌的治疗方法已显示出巨大的潜力。一些研究表明，干细胞的治疗效果根据细胞给药的时间而变化。已经清楚地确定，心肌梗死后经历时间依赖性的刚度变化，并且许多研究已经强调了微环境的刚度（弹性）对调节干细胞的命运和功能的重要性。因此，本章概述了我们的研究和其他实验，旨在建立最佳刚度的微环境，最大限度地提高效益，维持细胞存活，促进表型可塑性，并提高功能规格的移植干细胞。
Cardiovascular diseases related to myocardial infarction (MI) contribute significantly to morbidity and mortality worldwide. The loss of cardiomyocytes during MI is a key factor in the impairment of cardiac-pump functions. Employing cell transplantation has shown great potential as a therapeutic approach in regenerating ischemic myocardium. Several studies have suggested that the therapeutic effects of stem cells vary based on the timing of cell administration. It has been clearly established that the myocardium post-infarction experiences a time-dependent stiffness change, and many studies have highlighted the importance of stiffness (elasticity) of microenvironment on modulating the fate and function of stem cells. Therefore, this chapter outlines our studies and other experiments designed to establish the optimal stiffness of microenvironment that maximizes benefits for maintaining cell survival, promoting phenotypic plasticity, and improving functional specification of the engrafted stem cells.