Can we measure serum thyroglobulin?
Can we measure serum thyroglobulin?
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DOI：
10.1258/0004563021902125
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发表时间：
2002-05-01
影响因子：
2.2
通讯作者：
Beckett, G
中科院分区：
文献类型：
--
作者：
Clark, PM;Beckett, G
免疫分析法测定血清甲状腺球蛋白（Tg）用于监测分化型甲状腺癌的治疗情况。对疾病过程和Tg生物化学的理解使实验室能够确定合适的Tg分析的特征。有许多关键的分析问题：标准化，长期分析稳定性，最低检出限，工作范围和内源性Tg抗体（TgAb）的影响。用于测定TgAb干扰的方法有明显的局限性。临床医生应该意识到这种肿瘤标志物的免疫测定的局限性。
Measurement of serum thyroglobulin (Tg) by immunoassay is used to monitor the treatment of differentiated thyroid cancer. An understanding of the disease process and the biochemistry of Tg allows the laboratory to determine the characteristics of suitable Tg assays. There are a number of key analytical issues: standardization, long-term assay stability, minimum detection limit, working range and the effect of endogenous Tg antibodies (TgAb). There are significant limitations to the methods used to determine TgAb interference. Clinicians should be aware of the limitations of immunoassays for this tumour marker.