Role of Osteopathic Manipulative Treatment in Altering Pain Biomarkers: A Pilot Study
Role of Osteopathic Manipulative Treatment in Altering Pain Biomarkers: A Pilot Study
复制标题
整骨手法治疗在改变疼痛生物标志物中的作用：一项试点研究
DOI：
--
复制
发表时间：
2007
期刊：
影响因子：
--
通讯作者：
V. DiMarzo
中科院分区：
文献类型：
--
作者：
B. Degenhardt;N. Darmani;Jane C. Johnson;L. Towns;Diana C. J. Rhodes;Chung Trinh;Bryan A. McClanahan;V. DiMarzo
Abstract Context: Underlying mechanisms explaining the effects of osteopathic manipulative treatment (OMT) are poorly defined. The authors evaluate various nociceptive (pain) biomarkers that have been suggested as important mediators in this process. Objective: To determine if OMT influences levels of circulatory pain biomarkers. Methods: In a prospective, blinded assessment, blood was collected from 20 subjects (10 with chronic low back pain [LBP], 10 controls without chronic LBP) for 5 consecutive days. On day 4, OMT was administered to subjects 1 hour before blood collection. Blood was analyzed for levels of β-endorphin (βE), serotonin (5-hydroxytryptamine [5-HT]), 5-hydroxyindoleacetic acid (5-HIAA), anandamide (arachidonoylethanolamide [AEA]), and N-palmitoylethanolamide (PEA). A daily questionnaire was used to monitor confounding factors, including pain and stress levels, sleep patterns, and substance use. Results: Increases from baseline in βE and PEA levels and a decrease in AEA levels occurred immediately posttreatment. At 24 hours posttreatment, similar biomarker changes from baseline were observed. A decrease in stress occurred from baseline to day 5. The change in PEA from baseline to 24 hours posttreatment correlated with the corresponding changes in stress. Subgroup analysis showed that subjects with chronic LBP had significantly reduced 5-HIAA levels at 30 minutes posttreatment (P=.05) and 5-HT levels at 24 hours posttreatment (P=.02) when compared with baseline concentrations. The increase in PEA in subjects with chronic LBP at 30 minutes posttreatment was two times greater than the increase in control subjects. Conclusion: Concentrations of several circulatory pain biomarkers were altered after OMT. The degree and duration of these changes were greater in subjects with chronic LBP than in control subjects without the disorder.
DOI：
10.1073/pnas.96.21.12198
发表时间：
1999-10-12
影响因子：
11.1
作者：
Walker, JM;Huang, SM;Sañudo-Peña, MC
通讯作者：
Sañudo-Peña, MC