Human papillomavirus type 16 late gene expression is regulated by cellular RNA processing factors in response to epithelial differentiation
Human papillomavirus type 16 late gene expression is regulated by cellular RNA processing factors in response to epithelial differentiation
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DOI：
10.1042/bst0360522
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发表时间：
2008-06-01
影响因子：
3.9
通讯作者：
Graham, Sheila V.
中科院分区：
文献类型：
--
作者：
Cumming, Sarah A.;Cheun-Im, Thanaporn;Graham, Sheila V.
HPV16（人乳头瘤病毒16型）是一种7.9 kb的双链DNA病毒，感染肛门生殖器粘膜上皮。在一些罕见的情况下，在女性中，感染可以发展为宫颈癌。HPV16基因表达通过使用多个启动子和选择性剪接和聚腺苷化来调节。病毒基因组可分为早期编码区和晚期编码区。晚期编码区包含L1和L2基因。它们编码病毒衣壳蛋白L1和L2；蛋白表达局限于上上皮层，转录后受上皮分化的调节。参与这一调控的79nt RNA调控元件LRE（后期调控元件）位于L1基因的3‘端，并延伸到3’-UTR（3'-未翻译区）晚期。该元件抑制分化上皮细胞的晚期基因表达，并可能在分化细胞中激活它。本文介绍了我们目前对LRE rna -蛋白相互作用及其可能功能的了解。
HPV16 (human papillomavirus type 16) is a 7.9 kb double-stranded DNA virus that infects anogenital mucosal epithelia. in some rare cases, in women, infection can progress to cervical cancer. HPV16 gene expression is regulated through use of multiple promoters and alternative splicing and polyadenylation. The virus genome can be divided into an early and a late coding region. The late coding region contains the L1 and L2 genes. These encode the virus capsid proteins L1 and L2; protein expression is confined to the upper epithelial layers and is regulated post-transcriptionally in response to epithelial differentiation. A 79 nt RNA regulatory element, the LRE (late regulatory element), involved in this regulation is sited at the 3'-end of the L1 gene and extends into the late 3'-UTR (3'-untranslated region). This element represses late gene expression in differentiated epithelial cells and may activate it in differentiated cells. The present paper describes our current knowledge of LRE RNA-protein interaction and their possible functions.