Optimal tuning of bacterial sensing potential
Optimal tuning of bacterial sensing potential
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DOI：
10.1038/msb.2009.43
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发表时间：
2009-07-01
影响因子：
9.9
通讯作者：
You, Lingchong
中科院分区：
文献类型：
--
作者：
Pai, Anand;You, Lingchong
通过产生和感受小信号分子，群体感应（QS）使细菌能够检测其密度的变化并相应地调节其功能。QS系统在其特定的感觉组分、信号分子的生化和运输性质、其靶功能以及QS介导的功能被激活的背景方面是非常多样的。然而，跨越这种多样性，QS系统的中心架构是通用的;它包括信号合成、分泌、降解和检测。因此，我们能够基于这个“核心”模块推导出QS“感知潜力”的一般度量。传感电位量化了单个细菌感知其微环境尺寸的能力。这个简单的度量捕获了不同QS系统的主要激活特性，给出了感测特性的简明描述。因此，它提供了一个方便的定量框架来研究QS特征的表型效应。作为一个例子，我们展示了如何独特的QS特性确定的情况下，一个典型的QS控制的功能，如胞外酶分泌的调节，变得有利。Molecular Systems Biology 5：286; 2009年7月7日在线发表; doi：10.1038/msb.2009.43
Through production and sensing of small signal molecules, quorum sensing (QS) enables bacteria to detect changes in their density and regulate their functions accordingly. QS systems are tremendously diverse in terms of their specific sensory components, the biochemical and transport properties of signaling molecules, their target functions and the context in which QS-mediated functions are activated. Cutting across this diversity, however, the central architecture of QS systems is universal; it comprises signal synthesis, secretion, degradation and detection. We are thus able to derive a general metric for QS 'sensing potential' based on this 'core' module. The sensing potential quantifies the ability of a single bacterium to sense the dimensions of its microenvironment. This simple metric captures the dominant activation properties of diverse QS systems, giving a concise description of the sensing characteristics. As such, it provides a convenient quantitative framework to study the phenotypic effects of QS characteristics. As an example, we show how QS characteristics uniquely determine the scenarios in which regulation of a typical QS-controlled function, such as exoenzyme secretion, becomes advantageous. Molecular Systems Biology 5: 286; published online 7 July 2009; doi:10.1038/msb.2009.43