HIGH BLOOD ACETALDEHYDE LEVELS AFTER ETHANOL ADMINISTRATION - DIFFERENCE BETWEEN ALCOHOLIC AND NONALCOHOLIC SUBJECTS
HIGH BLOOD ACETALDEHYDE LEVELS AFTER ETHANOL ADMINISTRATION - DIFFERENCE BETWEEN ALCOHOLIC AND NONALCOHOLIC SUBJECTS
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DOI：
10.1056/nejm197502202920802
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发表时间：
1975-01-01
影响因子：
158.5
通讯作者：
LIEBER, CS
中科院分区：
文献类型：
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作者：
KORSTEN, MA;MATSUZAKI, S;LIEBER, CS
在静脉注射酒精后，对11名受试者的血液乙醛和乙醇水平进行了测定，其中6名为慢性酒精中毒者，5名为非酒精对照组。尽管血液中的乙醇含量在54到33 mm的范围内逐渐下降，但乙醛在11名受试者中的任何一个都没有下降。酒精组平均乙醛平台水平(42.7±1.2μM)显著高于非酒精组(2 6.5±1.5μM)(p<；0.001)。当平均血液乙醇浓度达到24 mM时，每个受试者的乙醛平台突然结束。血液乙醛下降时的乙醇浓度表明乙醇脱氢酶以外的乙醇氧化系统降低了饱和度，并表明在高乙醇血液水平下，这样的系统有助于乙醇氧化。酒精中毒时乙醛水平升高可能是该系统活性增强和线粒体损伤的结果，并可能导致酒精中毒的神经系统、肝脏和心脏并发症。(N Engl J Med 292：386-389,1975)
Blood acetaldehyde and ethanol levels were measured in 11 subjects, six with chronic alcoholism and five nonalcoholic controls, after alcohol had been given intravenously. Despite a progressive fall in blood ethanol over a range of 54 to 33 mM, acetaldehyde did not decrease in any of the 11 subjects. The mean acetaldehyde plateau level was significantly (p < 0.001) higher in alcoholic (42.7 ± 1.2 μM) than in nonalcoholic (26.5 ± 1.5 μM) subjects. When the mean blood ethanol concentration reached 24 mM, the acetaldehyde plateau ended abruptly in each subject. The ethanol concentration at which this fall of blood acetaldehyde occurred suggests desaturation of an ethanol oxidizing system other than alcohol dehydrogenase and indicates that at high ethanol blood levels, such a system contributes to ethanol oxidation. The higher acetaldehyde levels in alcoholism may result from both greater activity of this system and mitochondrial damage, and could contribute to the neurologic, hepatic and cardiac complications of alcoholism. (N Engl J Med 292:386–389, 1975)