Effective treatment of multidrug-resistant enterococcal experimental endocarditis with combinations of cell wall-active agents
Effective treatment of multidrug-resistant enterococcal experimental endocarditis with combinations of cell wall-active agents
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DOI：
10.1093/infdis/173.4.909
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发表时间：
1996-04-01
影响因子：
6.4
通讯作者：
Steckelberg, JM
中科院分区：
文献类型：
--
作者：
Brandt, CM;Rouse, MS;Steckelberg, JM
在实验性心内膜炎模型中，使用对万古霉素具有高水平耐药性和对氨苄青霉素和亚胺培南具有中等内在耐药性的屎肠球菌菌株，将氨苄青霉素、亚胺培南和万古霉素的组合治疗的功效与两种药物组合或单一疗法的功效进行比较。体外时间杀灭协同作用研究仅证明了三联组合的杀菌协同活性。万古霉素单药治疗无效，单独或与万古霉素联合使用氨比西林或亚胺培南治疗导致
The efficacy of treatment with a combination of ampicillin, imipenem, and vancomycin was compared with that of two-drug combinations or monotherapy in a model of experimental endocarditis using a strain of Enterococcus faecium with high-level resistance to vancomycin and moderate intrinsic resistance to ampicillin and imipenem, In vitro time-kill synergy studies demonstrated bactericidal synergistic activity only for the triple combination, In vivo, monotherapy with vancomycin was not effective, Treatment with either ampicillin or imipenem alone or in combination with vancomycin resulted in