Electroconvulsive shock but not antidepressant drugs increases alpha 1-adrenoceptor binding sites in rat brain.
Electroconvulsive shock but not antidepressant drugs increases alpha 1-adrenoceptor binding sites in rat brain.
复制标题
电休克会增加大鼠大脑中的α1-肾上腺素受体结合位点，但抗抑郁药物不会增加。
DOI：
10.1016/0014-2999(87)90582-6
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发表时间：
1987
影响因子：
5
通讯作者：
Kellar,KJ
中科院分区：
文献类型：
--
作者：
Stockmeier,CA;McLeskey,SW;Blendy,JA;Armstrong,NR;Kellar,KJ
电休克处理大鼠10-12天，可使额叶皮质匀浆中[~ 3 H]哌唑嗪标记的α_1-肾上腺素能受体密度增加。单次给药不影响[3 H]哌唑嗪结合。重复电休克治疗似乎不影响海马或下丘脑中α1-肾上腺素受体的结合。利血平治疗大鼠也增加[3 H]哌唑嗪结合在额叶皮质。与电休克相反，三环类抗抑郁药、单胺氧化酶抑制剂或非典型抗抑郁药给药3周对额叶皮质[3 H]哌唑嗪结合位点无显著影响。抗抑郁药对α1-肾上腺素受体的亲和力范围从三环类和非典型抗抑郁药的约50 nM到单胺氧化酶抑制剂的约100 μM。三环类和非典型抗抑郁药对α1-肾上腺素受体的高亲和力可能导致这些药物与单胺氧化酶抑制剂之间的临床差异。此外，电休克诱导的α1-肾上腺素受体增加可能导致该治疗与抗抑郁药物之间的临床效果差异。
Treatment of rats with electroconvulsive shock once daily for 10–12 days increased the density ofα1-adrenoceptors labeled by [3H]prazosin in homogenates of frontal cerebral cortex. A single treatment did not affect [3H]prazosin binding. Repeated treatment with electroconvulsive shock did not appear to affectα1-adrenoceptor binding in the hippocampus or hypothalamus. Treatment of rats with reserpine also increased [3H]prazosin binding in the frontal cortex. In contrast to electroconvulsive shock, three weeks administration of tricyclic antidepressant drugs, monoamine oxidase inhibitors, or atypical antidepressant drugs did not significantly affect [3H]prazosin binding sites in the frontal cortex. The affinities of antidepressant drugs forα1-adrenoceptors ranged from about 50 nM for tricyclic and atypical antidepressants to about 100 μM for monoamine oxidase inhibitors. The high affinities of the tricyclic and atypical antidepressant drugs forα1-adrenoceptors could contribute to clinical differences between these classes of drugs and monoamine oxidase inhibitors. Furthermore, the electroconvulsive shock-induced increase inα1-adrenoceptors could contribute to differences in clinical effects between this treatment and antidepressant drugs.