Biomimetic iterative method for polyketide synthesis
Biomimetic iterative method for polyketide synthesis
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DOI：
10.1039/c7cc04033d
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发表时间：
2017-08-11
影响因子：
4.9
通讯作者：
Kudo, Kazuaki
中科院分区：
文献类型：
--
作者：
Akagawa, Kengo;Kudo, Kazuaki
提出了一种合成聚酮化合物的迭代方法，其中羧酸的扩链是通过与丙二酸半硫酯的脱羧脱水缩合进行的。在将所得β-酮硫酯转化成适当形式后，再生羧酸官能团用于下一个延伸步骤。
An iterative method for synthesizing polyketides was demonstrated, in which the chain elongation of a carboxylic acid was performed by decarboxylative dehydration condensation with a malonic acid half thioester. After transforming the resulting beta-ketothioester into an appropriate form, the carboxylic acid functionality was regenerated for the next elongation step.