Infant vitamin D supplementation and allergic conditions in adulthood -: Northern Finland Birth Cohort 1966
Infant vitamin D supplementation and allergic conditions in adulthood -: Northern Finland Birth Cohort 1966
复制标题
DOI：
10.1196/annals.1337.013
复制
发表时间：
2004-01-01
期刊：
影响因子：
--
通讯作者：
Järvelin, MR
中科院分区：
文献类型：
--
作者：
Hyppönen, E;Sovio, U;Järvelin, MR
最近有报道称，在维生素D的活性形式1,25(OH)(2)D治疗的小鼠中，过敏原诱导的th2型细胞因子分泌和IgE产生增加。我们的目的是研究婴儿期补充维生素D是否与特应性、变应性鼻炎和哮喘的风险相关。芬兰北部出生队列4由芬兰最北部两个省份的所有将于1966年出生的人组成。1967年获得了婴儿出生后第一年补充维生素D的数据。目前患有哮喘和过敏性鼻炎的患者年龄为31岁（n = 7648），并通过皮肤点刺试验在仍居住在芬兰北部或赫尔辛基地区的亚样本中确定了特应性（n = 5007）。在31岁时，在第一年定期补充维生素D的参与者中，特应性和过敏性鼻炎的患病率高于其他人（OR分别为1.46,95% CI 1.4-2.0， OR为1.66,95% CI 1.1-1.6）。哮喘也有类似的相关性（OR 1.35, 95% CI 0.99-1.8）。在调整了广泛的行为和社会因素后，这些关联仍然存在（调整后：OR 133， P = 0.01）。过敏性鼻炎P = 0.001，哮喘P = 0.08)。我们观察到婴儿时期补充维生素D与以后患特应性和过敏性鼻炎的风险增加之间存在关联。需要进一步的研究来确定这些观察结果是否反映了免疫调节的长期影响或维生素D补充的未测量决定因素的差异。
Allergen-induced secretion of Th2-type cytokines and IgE production have recently been reported to be increased in mice treated with 1,25(OH)(2)D, the active form of vitamin D. Our objective was to investigate whether vitamin D supplementation in infancy is associated with the risk of atopy, allergic rhinitis, and asthma. The Northern Finland Birth Cohort 4-onsists of all individuals in the two most northern provinces of Finland who were due to be born in 1966. Data on vitamin D supplementation during the first year of life was obtained in 1967. Current asthma and allergic rhinitis were reported at age 31 years (n = 7,648), and atopy determined by skin-prick test in a sub-sample still living in northern Finland or the Helsinki area (n = 5,007). The prevalence of atopy and allergic rhinitis at age 31 years was higher in Participants who had received vitamin D supplementation regularly during the first year compared to others (OR 1.46, 95% CI 1.4-2.0, and OR 1.66, 95% CI 1.1-1.6, respectively). A similar association was observed for asthma (OR 1.35, 95% CI 0.99-1.8). These associations persisted after adjustment for a wide range of behavioral and social factors (adjusted: OR 133 for all, P = 0.01. for atopy, P = 0.001 for allergic rhinitis, and P = 0.08 for asthma). We observed an association between, vitamin D supplementation in infancy and an increased risk of atopy and allergic rhinitis later in life. Further study is required to determine whether these observations reflect long-term effects on immune regulation or differences in unmeasured determinants of vitamin D supplementation.