The prevalence of diffuse idiopathic skeletal hyperostosis (DISH) in two large American Midwest metropolitan hospital populations
The prevalence of diffuse idiopathic skeletal hyperostosis (DISH) in two large American Midwest metropolitan hospital populations
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DOI：
10.1007/s002560050225
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发表时间：
1997-04-01
影响因子：
2.1
通讯作者：
Griffiths, HJ
中科院分区：
文献类型：
--
作者：
Weinfeld, RM;Olson, PN;Griffiths, HJ
目标。目前还没有关于弥漫性特发性骨骼肥厚症（DISH）总体患病率的大规模研究发表，有人认为其患病率高于先前报道。因此，我们决定回顾在美国中西部一个主要城市的两家大型但不同的大都会医院就诊的50岁以上患者的胸部x线片。设计和病人。我们回顾了1363例患者在明尼苏达大学医院和诊所的前后位和侧位胸片，以寻找DISH的证据。有500名连续住院病人，540名连续门诊病人和326名从我们的电影档案中收集的病人。研究人员还对亨内平县医疗中心的1001名患者进行了研究。可以根据种族对后一类人进行再分类。结果与结论。使用严格的标准，即涉及四个或更多水平，50岁以上男性人群中DISH的总体患病率为25%，50岁以上女性人群中患病率为15%。80岁以上男性的患病率攀升至28%，70岁以上男性的患病率攀升至35%以上。在80岁以上的女性中，患病率为26%。虽然我们的人口基数很小，但DISH在黑人、美洲原住民和亚洲人群中并不常见。研究还发现，在患有骨质疏松症的类似白人人群中，DISH的患病率要低得多。在50岁以上以白人为主的人群中，DISH的总体患病率高于预期，而在黑人中发病率较低。美洲原住民和亚洲人，这表明这种疾病的遗传起源。
Objective. There are no published large-scale studies of the overall prevalence of diffuse idiopathic skeletal hyperostosis (DISH) and it has been proposed that the prevalence is greater than previously reported. We thus decided to review chest radiographs in a population of patients over 50 years of age seen at two large bur differing metropolitan hospitals in a major American Midwest city.Design and patients. The posterior-anterior and lateral chest radiographs of 1363 patients were reviewed for evidence of DISH at the University of Minnesota Hospital and Clinic. There were 500 consecutive inpatient admissions, 540 consecutive patients who attended the outpatient clinics and 326 patients collected from our film archive. A population of 1001 patients seen at Hennepin County Medical Center was also studied. It was possible to subclassify this latter group with respect to race.Results and conclusion. Using strict criteria, i.e., four or more levels involved, the overall prevalence of DISH in the male population over age 50 years was 25% and in the female population over age 50 years was 15%. This prevalence climbed to 28% in males over 80 years and to over 35% in males over age 70 years. In females over 80 years, the prevalence was found to be 26%. Although our population base was small, DISH was found to be less common in the black, Native-American and Asian populations. The prevalence of DISH was also found to be far lower in a similar white population with osteoporosis. The overall prevalence of DISH was higher than expected in a predominantly white population over age 50 years with a lesser incidence in the black. Native-American and Asian populations, suggesting a genetic origin of the condition.