Type III secretion systems: Machines to deliver bacterial proteins into eukaryotic cells?
Type III secretion systems: Machines to deliver bacterial proteins into eukaryotic cells?
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DOI：
10.1016/s0966-842x(97)01029-9
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发表时间：
1997-04-01
影响因子：
15.9
通讯作者：
Lee, CA
中科院分区：
文献类型：
--
作者：
Lee, CA
某些细菌病原体中的III型分泌系统在与宿主细胞接触时被诱导，并直接将毒力蛋白递送到宿主细胞胞质溶胶中。越来越多的革兰氏阴性细菌病原体发现编码III型分泌系统提出了有趣的问题。BI型系统是将毒力蛋白递送到宿主细胞中的通用机器吗？与宿主细胞的接触是III型系统的共同调节线索吗？
Type III secretion systems in certain bacterial pathogens are induced upon contact with host cells and directly deliver virulence proteins into the host cell cytosol. The increasing number of Gram-negative bacterial pathogens discovered to encode type III secretion systems raises interesting questions. Are type BI systems generic machines that deliver virulence proteins into host cells? Is contact with host cells a common regulatory cue for type III systems?