Enhancement of rigidity in Parkinson's disease with activation
Enhancement of rigidity in Parkinson's disease with activation
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DOI：
10.1002/mds.21524
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发表时间：
2007-06-15
影响因子：
8.6
通讯作者：
Earhart, Gammon M.
中科院分区：
文献类型：
--
作者：
Hong, Minna;Perlmutter, Joel S.;Earhart, Gammon M.
僵硬是帕金森病（PD）的主要症状，随着对侧肢体的运动而增加。目前还不清楚这种效应是否是特定的对侧肢体的运动。本研究的目的是检验这一假设，同侧或对侧的运动会增加刚性，但双边肢体运动会最大限度地增加刚性与PD的人。我们使用僵硬度分析仪（Neurokinetics，阿尔伯塔，加拿大）评估了12名停药PD患者、12名匹配对照组和10名年轻对照组的僵硬度。手肘被动地反复移动到屈曲和伸展的检查者，而受试者从事不同的脚趾轻敲条件：没有轻敲，同侧轻敲，对侧轻敲，双侧轻敲。每种条件下进行三次50秒的试验，试验顺序随机。使用双因素重复测量ANOVA和Holm-Sidak事后检验来确定条件和组之间的差异。有一个显着的效果组，割胶条件和两者的交互作用。事后检验显示，对于PD组，所有攻丝条件与无攻丝条件均显著不同，但彼此无差异。对照品在不同条件下无差异。结论：运动对侧或同侧下肢均可增加PD患者的手臂僵硬度，但左右侧下肢运动的作用呈明显的点加性。此外，激活并没有增强对照组的肌肉张力，这表明该程序可能有助于区分PD患者和对照组。(c)2007年，《社会运动》创刊。
Rigidity, a cardinal symptom of Parkinson's disease (PD), increases with movement of a contralateral limb. It is unclear whether this effect is specific for movement of a contralateral limb. The goal of this study was to test the hypothesis that ipsilateral or contralateral movement would enhance rigidity but that bilateral limb movements would maximally increase rigidity in people with PD. We assessed rigidity in 12 people with PD off meds, 12 matched controls, and 10 young controls, using a Rigidity Analyzer (Neurokinetics, Alberta, Canada). The elbow was passively moved repetitively into flexion and extension by the examiner, while the subjects engaged in different toe tapping conditions: no tapping, ipsilateral tapping, contralateral tapping, and bilateral tapping. Three 50-second trials were done for each condition and the order of the trials was randomized. A 2-way repeated measures ANOVA and Holm-Sidak post hoc tests were used to determine differences across conditions and groups. There was a significant effect of group, tapping conditions and an interaction of the two. Post hoc tests revealed that for the PD group, all tapping conditions were significantly different from the no tapping condition but not different from each other. There were no differences across conditions for the controls. We conclude that movement of either the contralateral or ipsilateral lower extremity can increase arm rigidity in people with PD but the effects from left and right are apparently Dot additive. Further, activation did not enhance muscle tone in controls suggesting that this procedure may help distinguish people with PD from controls. (c) 2007 Movement Disorder Society.