Subversion of autophagy machinery and organelle-specific autophagy by SARS-CoV-2 and coronaviruses.
Subversion of autophagy machinery and organelle-specific autophagy by SARS-CoV-2 and coronaviruses.
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DOI：
10.1080/15548627.2022.2116677
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发表时间：
2022
期刊：
影响因子：
13.3
通讯作者：
Ersheng Kuang
中科院分区：
文献类型：
--
作者：
Qinqin Sun;Xiaojuan Li;Ersheng Kuang
As a new emerging severe coronavirus, the knowledge on the SARS-CoV-2 and COVID-19 remains very limited, whereas many concepts can be learned from the homologous coronaviruses. Macroautophagy/autophagy is finely regulated by SARS-CoV-2 infection and plays important roles in SARS-CoV-2 infection and pathogenesis. This review will explore the subversion and mechanism of the autophagy-related machinery, vacuoles and organelle-specific autophagy during infection of SARS-CoV-2 and coronaviruses to provide meaningful insights into the autophagy-related therapeutic strategies for infectious diseases of SARS-CoV-2 and coronaviruses.
