A randomized controlled psycho-education intervention trial: Improving psychological readiness for successful HIV medication adherence and reducing depression before initiating HAART
A randomized controlled psycho-education intervention trial: Improving psychological readiness for successful HIV medication adherence and reducing depression before initiating HAART
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DOI：
10.1080/09540120500466820
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发表时间：
2006-10-01
影响因子：
1.7
通讯作者：
Cameron, D. W.
中科院分区：
文献类型：
--
作者：
Balfour, L.;Kowal, J.;Cameron, D. W.
这项研究的目的是评估一种新的心理教育干预措施，旨在提高患者在开始高效抗逆转录病毒治疗(HAART)之前的用药准备和治疗依从性技能。63名目前没有接受抗逆转录病毒治疗的艾滋病毒阳性患者参加了一项标准化的、为期四个疗程的心理教育干预(坚持抗逆转录病毒治疗的支持性疗法；STAART)的随机对照试验。会议主题包括学习提高服药依从性的技术，以及学习应对压力和抑郁的有效策略。患者完成心理问卷，评估启动HAART的心理准备情况和抑郁情绪。他们在研究基线和基线后四周完成了这两项测量。在控制了基线服药准备分数后，干预患者(n=30)在STAART干预后(基线后四周)报告的平均服药准备程度(27.39/6.9)显著高于对照组(n=33；24.6+/-9.9；p<；0.05)。在27名抑郁症患者中，接受干预的患者(n=15)在基线后4周报告的平均抑郁评分(22.59/12.9)显著低于对照组(n=12；279/9.9；p0.05)。STAART干预通过在启动HAART之前更好地为患者做好准备，提高了HIV治疗的准备程度。它还有利于减轻抑郁、HIV阳性患者的抑郁症状。
The purpose of this study was to evaluate a novel psycho-educational intervention intended to increase patients' medication preparedness and treatment adherence skills before initiating highly active antiretroviral therapy (HAART). Sixty-three HIV-positive patients not currently on antiretroviral therapy participated in a randomized controlled trial of a standardized, four-session psycho-educational intervention (Supportive Therapy for Adherence to Antiretroviral Treatment; STAART). Session topics included learning techniques to increase medication adherence and learning effective strategies to cope with stress and depression. Patients completed psychological questionnaires assessing psychological readiness to initiate HAART and depressed mood. They completed both measures at study baseline and at four-weeks post-baseline. After controlling for baseline medication readiness scores, intervention patients (n = 30) reported significantly higher mean medication readiness following the STAART intervention (four-weeks post-baseline) (27.39/6.9) compared to controls (n = 33; 24.6 +/- 9.9; p < 0.05). Among depressed patients (n = 27), those receiving the intervention (n = 15) reported significantly lower mean depression scores at four-weeks post-baseline (22.59/12.9) compared to controls (n = 12; 279/9.9; p0.05). The STAART intervention enhanced HIV treatment readiness by better preparing patients prior to initiating HAART. It was also beneficial for reducing depressive symptoms in depressed, HIV-positive patients.