Orientation, distance, regulation and function of neighbouring genes.
Orientation, distance, regulation and function of neighbouring genes.
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DOI：
10.1186/1479-7364-3-2-143
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发表时间：
2009-01
期刊：
影响因子：
4.5
通讯作者：
Avramopoulos D
中科院分区：
文献类型：
--
作者：
Gherman A;Wang R;Avramopoulos D
人类基因组的测序使我们能够全面和详细地观察染色体上基因的排列。有多条证据表明，这种排列不是随机的，无论是从基因间的距离还是从相邻基因的方向来看。我们已经对人类基因组中已知基因的空间分布和方向进行了系统的评估。我们使用基因组水平的信息，包括系统发育保守、单核苷酸多态密度和基因表达的相关性来评估这种分布的重要性。除了确认和扩展基因组的已知属性，如基因沙漠的重要性和邻近基因对‘头对头’方向的重要性，我们还提供了重要的新观察，包括相邻基因3‘端间隔的平均大小较小，相距100千碱基的基因在不同组织中表达的相关性，以及随着间隔大小的减少而增加的正选择的迹象，对于小于~500碱基对的间隔令人惊讶地放松。此外，我们提供了广泛的全基因组数据的图形表示，以允许观察和比较超出我们解决的范围。
The sequencing of the human genome has allowed us to observe globally and in detail the arrangement of genes along the chromosomes. There are multiple lines of evidence that this arrangement is not random, both in terms of intergenic distances and orientation of neighbouring genes. We have undertaken a systematic evaluation of the spatial distribution and orientation of known genes across the human genome. We used genome-level information, including phylogenetic conservation, single nucleotide polymorphism density and correlation of gene expression to assess the importance of this distribution. In addition to confirming and extending known properties of the genome, such as the significance of gene deserts and the importance of 'head to head' orientation of gene pairs in proximity, we provide significant new observations that include a smaller average size for intervals separating the 3' ends of neighbouring genes, a correlation of gene expression across tissues for genes as far as 100 kilobases apart and signatures of increasing positive selection with decreasing interval size surprisingly relaxing for intervals smaller than ~500 base pairs. Further, we provide extensive graphical representations of the genome-wide data to allow for observations and comparisons beyond what we address.