Human pulvinar functional organization and connectivity
Human pulvinar functional organization and connectivity
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DOI：
10.1002/hbm.22781
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发表时间：
2015-07-01
影响因子：
4.8
通讯作者：
Fox, Peter T.
中科院分区：
文献类型：
--
作者：
Barron, Daniel S.;Eickhoff, Simon B.;Fox, Peter T.
就大小和皮质连接而言，人类枕是丘脑中最大的区域。虽然我们对枕的局部结构解剖学了解很多，但对人类枕的功能解剖学却知之甚少。实验诱导的脑活动的共现是用于建立区域间脑连接的传统度量，并形成功能性神经成像连接分析的基础。由于功能性神经影像学研究报告了标准化空间内的任务相关共激活，因此许多全脑研究的荟萃分析可以定义大脑在许多任务中的区域间共激活。这种分析还可以检测和定义特定区域内功能共激活的变化。在这里，我们使用共激活档案报告约7,700功能性神经影像学研究包裹和定义枕的功能解剖。枕的共激活配置文件的Parcellation确定了五个集群每个枕不同的功能共激活。这些集群显示了高度的对称性，在半球和对应人类枕的细胞结构。我们研究了功能的共激活配置文件，每个由此产生的枕簇与荟萃分析方法。通过参考现有的神经影像学和病变缺陷的文献，这些配置文件使区域枕专业化的情况下，在更大的人类注意力控制网络。参考该文献还提供了具体的假设，可以在随后的健康和临床人群研究中进行检验。《脑地图》36：2417-2431，2015年。(c)2015 Wiley Periodicals，Inc.
The human pulvinar is the largest thalamic area in terms of size and cortical connectivity. Although much is known about regional pulvinar structural anatomy, relatively little is known about pulvinar functional anatomy in humans. Cooccurrence of experimentally induced brain activity is a traditional metric used to establish interregional brain connectivity and forms the foundation of functional neuroimaging connectivity analyses. Because functional neuroimaging studies report task-related coactivations within a standardized space, meta-analysis of many whole-brain studies can define the brain's interregional coactivation across many tasks. Such an analysis can also detect and define variations in functional coactivations within a particular region. Here we use coactivation profiles reported in approximate to 7,700 functional neuroimaging studies to parcellate and define the pulvinar's functional anatomy. Parcellation of the pulvinar's coactivation profile identified five clusters per pulvinar of distinct functional coactivation. These clusters showed a high degree of symmetry across hemispheres and correspondence with the human pulvinar's cytoarchitecture. We investigated the functional coactivation profiles of each resultant pulvinar cluster with meta-analytic methods. By referencing existent neuroimaging and lesion-deficit literature, these profiles make a case for regional pulvinar specialization within the larger human attention-controlling network. Reference to this literature also informs specific hypotheses that can be tested in subsequent studies in healthy and clinical populations. Hum Brain Mapp 36:2417-2431, 2015. (c) 2015 Wiley Periodicals, Inc.