Correlation of local interleukin-8 with immunoglobulin A against Gardnerella vaginalis hemolysin and with prolidase and sialidase levels in women with bacterial vaginosis
Correlation of local interleukin-8 with immunoglobulin A against Gardnerella vaginalis hemolysin and with prolidase and sialidase levels in women with bacterial vaginosis
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DOI：
10.1086/340417
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发表时间：
2002-06-01
影响因子：
6.4
通讯作者：
Quadrifoglio, F
中科院分区：
文献类型：
--
作者：
Cauci, S;Guaschino, S;Quadrifoglio, F
粘液免疫系统激活可能是细菌性阴道病（BV）相关不良后果的关键决定因素，如性人类免疫缺陷病毒传播、上生殖道感染、术后感染和不良妊娠结局。唾液酸酶，脯氨酰二肽酶，和抗加德纳菌溶血素（Gvh）免疫球蛋白A（伊加）的浓度较高，在阴道液中的75个生育妇女BV，与85个健康对照组的阴道液中的浓度相比。白细胞介素（IL）-8水平与抗Gvh伊加反应呈正相关，与BV妇女的高水平氨脯氨酸二肽酶和唾液酸酶呈负相关。IL-8浓度与健康和BV阳性妇女的白细胞计数密切相关。大多数BV患者中白细胞的缺乏可能是由于缺乏IL-8诱导。先天性和适应性粘膜免疫因子的平行损伤，可能通过微生物水解作用，可能使微生物上升到上生殖道，并可能促进病毒感染。
Mucosal immune system activation may represent a critical determinant of adverse consequences associated with bacterial vaginosis (BV), such as sexual human immunodeficiency virus transmission, upper genital tract infections, postsurgical infections, and adverse pregnancy outcomes. Concentrations of sialidase, prolidase, and anti-Gardnerella vaginalis hemolysin (Gvh) immunoglobulin A (IgA) were higher in vaginal fluids of 75 fertile women with BV, compared with concentrations in vaginal fluids of 85 healthy control subjects. Interleukin (IL)-8 levels were positively associated with anti-Gvh IgA response and inversely correlated with high levels of prolidase and sialidase in women with BV. IL-8 concentration was strongly associated with leukocyte count in both healthy and BV-positive women. The absence of leukocytes in most women with BV likely is due to lack of IL-8 induction. Parallel impairment of innate and adaptive mucosal immune factors, likely through microbial hydrolytic effects, may allow for the ascent of microorganisms to the upper genital tract and may facilitate viral infections.