Splenectomy in patients with sickle-cell disease
Splenectomy in patients with sickle-cell disease
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DOI：
10.1016/s0002-9610(96)00158-4
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发表时间：
1996-09-01
影响因子：
3
通讯作者：
AlJama, A
中科院分区：
文献类型：
--
作者：
AlSalem, AH;Qaisaruddin, S;AlJama, A
BACKGROUND: Splenic complications of sickle-cell disease (SCD) are associated with morbidity, and in some it may lead to mortality. This paper presents our experience with 43 patients with SCD who had splenectomy as part of their management.PATIENTS AND METHODS: The records of 43 patients with SCD who had splenectomy were examined for age at operation, sex, hemoglobin (Hb) electrophoresis, indication for splenectomy, pre- and postoperative medications, operative procedures, and postoperative complications.RESULTS: The indications for splenectomy were acute splenic sequestration crisis (ASSC) in 21 patients, hypersplenism in 15, and splenic abscess in 7. In 17 patients, the spleen was also found to be massively enlarged causing discomfort and intervening with everyday activity. For those with hypersplenism, there was a significant postoperative increase in total Hb (P
