Nerve growth factor is a neurotrophic factor for forebrain cholinergic neurons; implications for Alzheimer's disease.
Nerve growth factor is a neurotrophic factor for forebrain cholinergic neurons; implications for Alzheimer's disease.
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发表时间：
1987
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通讯作者：
F. Hefti;B. Will
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作者：
F. Hefti;B. Will
近年来的研究结果有力地证明了神经生长因子（NGF）是哺乳动物前脑胆碱能神经元的一种神经营养因子。在大鼠和人的前脑中，NFG受体仅局限于这些神经元上。在体内和体外实验中，NGF促进前脑胆碱能神经元的存活、纤维伸长和递质特异性酶的表达。在成年大鼠中，脑室内注射NGF可减轻实验性病变后这些细胞的退化。这些发现表明，NGF可能能够减轻阿尔茨海默病中发生的胆碱能神经元的退化。
Findings obtained in recent years provide strong evidence that nerve growth factor (NGF) acts as a neurotrophic factor for cholinergic neurons of the mammalian forebrain. NFG receptors are exclusively localized on these neurons in the rat and human forebrain. NGF promotes survival, fiber elongation and expression of transmitter-specific enzymes of forebrain cholinergic neurons, in vivo and in vitro. In adult rats, intraventricular injections of NGF attenuate the degeneration of these cells after experimental lesions. These findings suggest that NGF might be able to attenuate the degeneration of cholinergic neurons occurring in Alzheimer's disease.