Serum soluble Klotho is inversely related to coronary artery calcification assessed by intravascular ultrasound in patients with stable coronary artery disease
Serum soluble Klotho is inversely related to coronary artery calcification assessed by intravascular ultrasound in patients with stable coronary artery disease
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DOI：
10.1016/j.jjcc.2020.11.014
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发表时间：
2021-06-01
影响因子：
2.5
通讯作者：
Maemura, Koji
中科院分区：
文献类型：
--
作者：
Koga, Seiji;Ikeda, Satoshi;Maemura, Koji
背景资料：尽管Klotho基因被认为是一种衰老抑制基因，但其可溶性产物可溶性Klotho在冠状动脉疾病（CAD）中的临床意义尚未完全确定。在稳定型CAD患者中研究可溶性Klotho与冠状动脉钙化（CAC）的关系。研究方法：分析了75例在血管内超声（IVUS）后计划接受经皮冠状动脉介入治疗（PCI）的稳定型CAD非透析患者中罪犯病变的CAC。主要的结果指标是钙指数（CalcIndex），这是一种体积IVUS衍生的每个罪犯病变总钙化的指标。低钙指数定义为第一四分位钙指数（< 0.042）。根据中位血清Klotho值将患者分为两组：低Klotho（n = 37，460 pg/mL）。结果：高Klotho患者的CalcIndex显著低于低Klotho患者。高Klotho患者的低钙指数患病率显著高于低Klotho患者。与低Klotho相比，高Klotho患者的全冠状动脉中血管造影中重度CAC数量显著减少。血清Klotho水平与CalcIndex呈显著负相关。这种关系在估计肾小球滤过率的患者中更为明显
Background: Although the Klotho gene is recognized as an aging-suppressor gene, the clinical significance of its soluble product, soluble Klotho, in coronary artery disease (CAD) has not been completely determined. The relationship between soluble Klotho and coronary artery calcification (CAC) was investigated in patients with stable CAD. Methods: CAC in culprit lesions was analyzed in 75 non-dialysis patients with stable CAD who were scheduled for percutaneous coronary intervention (PCI) following intravascular ultrasound (IVUS). The main outcome measure was the calcium index (CalcIndex), a volumetric IVUS-derived measure of total calcification per culprit lesion. A low CalcIndex was defined as a first-quartile calcium index (< 0.042). Patients were divided into two groups according to the median serum Klotho value: low Klotho (n = 37, 460 pg/mL). Results: The CalcIndex was significantly lower in patients with high than with low Klotho. Patients with high Klotho had a significantly higher prevalence of a low CalcIndex than those with low Klotho. The number of angiographic moderate-severe CACs in whole coronary arteries was significantly decreased in patients with high Klotho compared to low Klotho. Serum Klotho levels correlated significantly and inversely with the CalcIndex. This relationship was pronounced in patients with estimated glomerular filtration rate