Oncogenic CARD11 mutations in human diffuse large B cell lymphoma
Oncogenic CARD11 mutations in human diffuse large B cell lymphoma
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DOI：
10.1126/science.1153629
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发表时间：
2008-03-21
期刊：
影响因子：
56.9
通讯作者：
Staudt, Louis M.
中科院分区：
文献类型：
--
作者：
Lenz, Georg;Davis, R. Eric;Staudt, Louis M.
从多个可接受的选项中选择更好的选项的能力对动物优化其资源非常重要。这种决策过程背后的机制还没有得到很好的理解。我们发现黑腹果蝇的产卵地点选择是一个合适的系统来探测控制简单决策过程的神经回路。首先，雌性果蝇在产卵前会主动探测环境，显然是为了评估每个卵的位置质量。其次，雌性果蝇可以接受或拒绝含有蔗糖的培养基，这取决于环境。最后，生殖系统是否“接受”这种含有蔗糖的培养基作为产卵选择，取决于一组产生胰岛素样肽7 （ILP7）的神经元的功能。这些发现表明，产卵地点的选择涉及一个简单的决策过程，并为系统地解剖这一过程提供了一个切入点。
The ability to select a better option from multiple acceptable ones is important for animals to optimize their resources. The mechanisms that underlie such decision- making processes are not well understood. We found that selection of egg- laying site in Drosophila melanogaster is a suitable system to probe the neural circuit that governs simple decision- making processes. First, Drosophila females pursue active probing of the environment before depositing each egg, apparently to evaluate site quality for every egg. Second, Drosophila females can either accept or reject a sucrose- containing medium, depending on the context. Last, communication of the "acceptability" of the sucrose- containing medium as an egg- laying option to the reproductive system depends on the function of a group of insulin- like peptide 7 ( ILP7)- producing neurons. These findings suggest that selection of egg- laying site involves a simple decision- making process and provide an entry point toward a systematic dissection of this process.