Effect of treatment status on prepulse inhibition of acoustic startle in schizophrenia
Effect of treatment status on prepulse inhibition of acoustic startle in schizophrenia
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DOI：
10.1007/s00213-002-1372-z
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发表时间：
2003-04-01
影响因子：
3.4
通讯作者：
Rotrosen, JP
中科院分区：
文献类型：
--
作者：
Duncan, EJ;Szilagyi, S;Rotrosen, JP
基本原理：当惊吓刺激之前有较弱的非惊吓声刺激时，声惊吓反应会受到抑制。这种现象被称为声惊吓的前脉冲抑制（PPI），与正常对照相比，精神分裂症患者的这种现象受到损害。迄今为止，关于 PPI 损伤是否会随着抗精神病治疗而改善，存在相互矛盾的证据。目的：检查药物状态对精神分裂症受试者 PPI 的影响。方法：首先，我们对 16 名精神分裂症受试者进行了声学惊吓测试，当时他们因药物治疗而严重失代偿，后来在抗精神病药物治疗稳定后。其次，在组间设计中，我们测试了 21 名未接受药物治疗的精神分裂症受试者、16 名服用非典型抗精神病药的受试者和 27 名服用典型抗精神病药的受试者。结果：在重测研究和组间研究中，方差分析显示治疗条件之间的惊吓到脉冲单独刺激、惊吓到脉冲单独刺激的习惯、PPI、反应开始潜伏期或反应峰值潜伏期没有显着变化。结论：我们的结果并不支持精神分裂症患者感觉运动门控受损可通过抗精神病药物治疗得到改善的假设。相反，尽管药物治疗症状有所改善，但门控受损仍然存在。
Rationale: The acoustic startle response is inhibited when the startling stimulus is preceded by a weaker non-startling acoustic stimulus. This phenomenon, termed prepulse inhibition of acoustic startle (PPI), is impaired in schizophrenics compared to normal controls. To date, there is conflicting evidence regarding whether PPI impairments improve with antipsychotic treatment. Objectives: To examine the effect of medication status on PPI in schizophrenic subjects. Methods: First, we performed acoustic startle testing on 16 schizophrenic subjects when they were acutely decompensated off medication and later after they were stabilized on antipsychotic treatment. Second, in a between-group design, we tested 21 schizophrenic subjects off medication, 16 subjects on atypical neuroleptics, and 27 subjects on typical neuroleptics. Results: In both the test-retest study and the between-group study, ANOVAs revealed no significant changes in startle to pulse alone stimuli, habituation of startle to pulse alone stimuli, PPI, latency to response onset, or latency to response peak between the treatment conditions. Conclusions: Our results do not support the hypothesis that impaired sensorimotor gating in schizophrenia improves with antipsychotic treatment. Rather, impaired gating persists despite symptomatic improvement on medication.