Chronic exposure to outdoor air pollution and lung function in adults
Chronic exposure to outdoor air pollution and lung function in adults
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DOI：
10.1136/thx.2008.109389
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发表时间：
2009-08-01
期刊：
影响因子：
10
通讯作者：
Anderson, H. R.
中科院分区：
文献类型：
--
作者：
Forbes, L. J. L.;Kapetanakis, V.;Anderson, H. R.
背景：慢性暴露于室外空气污染物对成人肺功能的影响程度尚不清楚。本研究的目的是测量慢性暴露于室外空气污染物与成人肺功能之间的关系。方法：通过1995年、1996年、1997年和2001年4次代表性的英国年龄>= 16岁人群的横断面调查，研究肺功能指标(1 s用力呼气量（FEV(1)）和FEV（1)占用力肺活量（FVC）的百分比）与平均暴露于直径< 10 μ m的颗粒物、二氧化氮、二氧化硫和臭氧之间的关系。使用固定效应荟萃分析汇总了特定年份的估计。结果：更多地暴露于直径< 10 μ m的颗粒物、二氧化氮和二氧化硫与较低的成人FEV有关(1)。当污染物浓度增加10 μ g/m时，颗粒物< 10 μ g/m对种群平均FEV(1)的影响约为3%，二氧化氮和二氧化硫对种群平均FEV(1)的影响约为0.7%。这种影响在男性、老年人和戒烟者中最为明显。FEV(1)与臭氧浓度无关。没有发现污染物和FEV(1)之间的关联，作为FVC的百分比。结论：慢性暴露于室外空气污染与成人FEV轻度降低有关(1)。
Background: The extent to which chronic exposure to outdoor air pollutants influences lung function in adults is unclear. The aim of this study was to measure the association between chronic exposure to outdoor air pollutants and adult lung function.Methods: The relationship between measures of lung function (forced expiratory volume in 1 s (FEV(1)) and FEV(1) as a percentage of forced vital capacity (FVC)) and average exposure to particulate matter < 10 mu m in diameter, nitrogen dioxide, sulfur dioxide and ozone was examined in four representative cross-sectional surveys of the English population aged >= 16 in 1995, 1996, 1997 and 2001. Year-specific estimates were pooled using fixed effects meta-analysis.Results: Greater exposure to particulate matter < 10 mu m in diameter, nitrogen dioxide and sulfur dioxide was associated with lower adult FEV(1). The size of the effect on population mean FEV(1) was about 3% for particulate matter < 10 mu m, and 0.7% for nitrogen dioxide and sulfur dioxide, for a 10 mu g/m(3) increase in pollutant concentration. The effects were most marked in men, older adults and ex-smokers. FEV(1) was not associated with ozone concentration. No associations were found between the pollutants and FEV(1) as a percentage of FVC.Conclusions: Chronic exposure to outdoor air pollution is associated with modestly reduced FEV(1) in adults.