Importance of Baseline Potency Rate Assessment of Men Diagnosed with Clinically Localized Prostate Cancer Prior to Radical Prostatectomy
Importance of Baseline Potency Rate Assessment of Men Diagnosed with Clinically Localized Prostate Cancer Prior to Radical Prostatectomy
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DOI：
10.1111/j.1743-6109.2008.01089.x
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发表时间：
2009-02-01
影响因子：
3.5
通讯作者：
Chun, Felix
中科院分区：
文献类型：
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作者：
Salomon, Georg;Isbarn, Hendrik;Chun, Felix
勃起功能障碍(ED)是一种常见的、多因素的医学问题，严重影响患者的生活质量。对于接受前列腺癌(PCA)治疗的男性来说，基线效力的知识非常重要，因为它可能会影响对治疗效果的判断，从而影响治疗决策。分析临床上局限性前列腺癌患者在根治性前列腺切除术(RP)前的基线效能率。此外，在双变量和多变量Logistic回归分析中，确定术前勃起功能障碍的并存因素，以及在双变量和多变量Logistic回归分析中，男性在手术前合并勃起功能障碍及其与勃起功能障碍之间的关系。对1330名可评估的PCa患者的大型单中心队列进行了回顾分析，这些患者在术前接受了国际勃起功能指数(IIEF)的5项简明版本的评估，也被描述为男性性健康问卷。描述了基线效力和共病发生率及其分布。对年龄、体重指数(BMI)、高脂蛋白血症(HLP)、非胰岛素依赖型糖尿病(NIDDM)、高血压和抑郁症与基线ED的风险进行了双变量和多变量Logistic回归分析。以IIEF-5的分界值21为标准，48%的患者存在不同程度的ED。重度、中度、轻中度、轻度和无ED发生率分别为9.2%、4.0%、10.2%、24.7%和52%。在单因素分析中，ED随年龄、BMI、HLP、高血压、NIDDM和抑郁症的增加而显著增加(P
Erectile dysfunction (ED) is a common, and multifactorial medical problem with significant impact on quality of life. Knowledge about baseline potency is highly important in men undergoing treatment for prostate cancer (PCa) as it might influence judgments about impact of treatment and thereby treatment decisions.To analyze the baseline potency rate of men with clinically localized PCa prior to radical prostatectomy (RP). Furthermore, it was of interest to identify comorbid factors of preoperative ED.Preavalence of preoperative ED and association between comorbidities and ED in men prior to RP in bi- and multivariable logistic regression analyses.Retrospective analysis of a large single center cohort of 1,330 evaluable PCa patients who were preoperatively assessed with the abridged 5-item version of the International Index of Erectile Function (IIEF) also described as Sexual Health Inventory for Men. Baseline potency and comorbidity rates, and their distribution were described. The risk of baseline ED associated with age, body mass index (BMI), the presence of hyperlipoproteinemia (HLP), non-insulin-dependent diabetes mellitus (NIDDM), hypertension, and depression were analyzed in bi- and multivariable logistic regression analyses.Using the IIEF-5 cutoff value of 21, 48% demonstrated some degree of ED. Severe, moderate, mild to moderate, mild, and no ED was observed in 9.2, 4.0, 10.2, 24.7, and 52% respectively. In univariable analyses, ED significantly increased according to increasing age, BMI, presence of HLP, hypertension, NIDDM, and depression (P