Association of bovine neonatal Fc receptor α-chain gene (FCGRT) haplotypes with serum IgG concentration in newborn calves
Association of bovine neonatal Fc receptor α-chain gene (FCGRT) haplotypes with serum IgG concentration in newborn calves
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DOI：
10.1007/s00335-002-2219-y
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发表时间：
2002-12-01
期刊：
影响因子：
2.5
通讯作者：
Besser, TE
中科院分区：
文献类型：
--
作者：
Laegreid, WW;Heaton, MP;Besser, TE
本报告描述了FCGRT（编码FcRn的α链）的等位基因变异及其与新生小牛I-G浓度变异的相关性。通过对来自96头牛和27头参考群体的建立者的多品种组的1305 bp的FCGRT基因组DNA进行测序，鉴定了5个SNP。这些SNPs定义了5种FCGRT单倍型，通过分离验证，并用于在病例对照研究中检测FCGRT与新生儿IgG浓度的相关性。本研究确定，FCGRT单倍型3的母畜在其小牛中被动转移失败的风险显著更大（比值比[OR] = 3.80，CI 95% 1.10-13.18 p = 0.035）。具有FCGRT单倍型2的小牛不太可能具有高水平的被动获得性免疫球蛋白（OR = 0.18，CI 95% 0.05-0.68，p = 0.011）。这些结果表明，牛FCGRT单倍型标记与影响肉牛IgG被动转移的遗传风险因素连锁不平衡，这是新生小牛发病率和死亡率的重要决定因素。
This report describes allelic variation in FCGRT (which encodes the alpha-chain of FcRn) and its association with variation of I-G concentration in neonatal calves. Five SNPs were identified by sequencing 1305 bp of FCGRT genomic DNA from a multi-breed panel of 96 cattle and 27 founders of a reference population. These SNPs defined five FCGRT haplotypes that were verified by segregation and used to test association of FCGRT with neonatal IgG concentration in a case-control study. This study established that dams with FCGRT haplotype 3 had a significantly greater risk of failure of passive transfer in their calves (odds ratio [OR] = 3.80, CI95% 1.10-13.18 p = 0.035). Calves with FCGRT haplotype 2 were less likely to have high levels of passively acquired immunoglobulin (OR = 0.18, CI95% 0.05-0.68, p = 0.011). These results indicate that the bovine FCGRT haplotype markers are in linkage disequilibrium with genetic risk factors affecting passive transfer of IgG in beef cattle, an important determinant of neonatal calf morbidity and mortality.