Medullary reticular formation activity during ingestion and rejection in the awake rat.
Medullary reticular formation activity during ingestion and rejection in the awake rat.
复制标题
清醒大鼠摄入和排斥过程中的髓质网状形成活动。
DOI：
10.1007/s002219900223
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发表时间：
2000
影响因子：
2
通讯作者：
Karimnamazi,H
中科院分区：
文献类型：
--
作者：
Travers,JB;DiNardo,LA;Karimnamazi,H
摄取和排斥的消耗性成分在尾侧脑干组织，包括舔、吞咽和口腔阶段的排斥(张口)。利用电刺激诱导的运动活动的研究已经定位了控制这些复杂运动模式的中间神经元到延髓网状结构(RF)，但这些神经元在更自然的诱导行为中的特征尚不清楚。本研究的目的是记录在舔、吞咽和口腔排斥反应中对味觉刺激作出反应的RF神经元的活动特征。从清醒、自由活动的大鼠记录到的202个神经元被大致分为口腔相关的(67%)和非口腔相关的(33%)。口腔相关神经元包括大量舔舔时有节律性活动的神经元(n=76；38%)。这些“舔节奏”神经元广泛分布于RF，但主要集中在紧邻舌下核的尾侧延髓网状结构(Probst‘s区)和RF中间区(IRT)的吻侧。一项自相关分析确定，这些区域的舔节奏神经元与舔舔的联系比与小细胞RF(PCRt)中更外侧的舔节奏神经元的耦合更密切。除了具有微弱舔咬节律活动的神经元外，PCRt还含有不成比例的具有口感或混合口感运动特性的神经元。这些数据为延髓RF不同区域的功能特化提供了证据。高比例的舔咬节律神经元也显示出与吞咽(41%)和/或张口(75%)相关的不同活动，进一步表明，摄取和排斥的不同成分共享脑干底物，而不是由独特的中间神经元亚群产生。
The consummatory components of ingestion and rejection, organized in the caudal brainstem, include licking, swallowing, and the oral phase of rejection (gaping). Studies employing electrical-stimulation induced motor activity have localized interneurons controlling these complex motor patterns to the medullary reticular formation (RF), but the characteristics of these neurons during more naturally induced behavior are unknown. The purpose of the present study was to record the activity profiles of RF neurons during licking, swallowing, and oral rejection in response to gustatory stimulation. Two-hundred and two neurons recorded from awake, freely moving rats were broadly classified as orally related (67%) or non-orally related (33%). Orally related neurons included a large number that were rhythmically active during licking (n=76; 38%). These "lick-rhythmic" neurons were widely distributed in the RF, but were concentrated in the caudal medullary reticular formation adjacent to the hypoglossal nucleus (Probst's region) and further rostral in the intermediate zone (IRt) of the RF. An analysis of autocorrelations determined that lick-rhythmic neurons in these regions were more closely coupled to licking than to lick-rhythmic neurons more lateral in the parvocellular RF (PCRt). In addition to neurons with weak lick-rhythmic activity, the PCRt also contained a disproportionate number of neurons with orosensory or mixed oro-sensorimotor properties. These data provide evidence for functional specialization within different regions of the medullary RF. A high proportion of lick-rhythmic neurons also showed differential activity associated with swallowing (41%) and/or gaping (75%), further suggesting that the different components of ingestion and rejection share brainstem substrates instead of being produced by unique subsets of interneurons.