Clinical consequences of altered chemoreflex control.

Clinical consequences of altered chemoreflex control.
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DOI:
10.1016/j.resp.2013.04.020
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发表时间:
2013-11-01
影响因子:
2.3
通讯作者:
Malhotra, Atul
Malhotra, Atul
中科院分区:
医学4区
文献类型:
--
作者:
Plataki, Maria;Sands, Scott A.;Malhotra, Atul

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Control of ventilation dictates various breathing patterns. The respiratory control system consists of a central pattern generator and several feedback mechanisms that act to maintain ventilation at optimal levels. The concept of loop gain has been employed to describe its stability and variability. Synthesizing all interactions under a general model that could account for every behavior has been challenging. Recent insight into the importance of these feedback systems may unveil therapeutic strategies for common ventilatory disturbances. In this review we will address the major mechanisms that have been proposed as mediators of some of the breathing patterns in health and disease that have raised controversies and discussion on ventilatory control over the years.
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