Glycosylated Nanoscale Surfaces: Preparation and Applications in Medicine and Molecular Biology
Glycosylated Nanoscale Surfaces: Preparation and Applications in Medicine and Molecular Biology
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DOI：
10.1002/chem.201204155
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发表时间：
2013-03-01
影响因子：
4.3
通讯作者：
Seeberger, Peter H.
中科院分区：
文献类型：
--
作者：
Kennedy, David C.;Gruenstein, Dan;Seeberger, Peter H.
细胞表面的碳水化合物是细胞外景观的关键组成部分，并有助于细胞信号传导、运动、粘附和识别。多价效应对于这些本质上很弱的相互作用是必不可少的。碳水化合物功能化表面满足了研究碳水化合物和其他生物分子之间的多价相互作用的重要需求。纳米材料的创新正在彻底改变这些碳水化合物界面的研究方式，并强调了它们在生物化学相互作用中的重要性。
Carbohydrates on cell surfaces are critical components of the extracellular landscape and contribute to cell signalling, motility, adhesion and recognition. Multivalent effects are essential to these interactions that are inherently weak. Carbohydrate-functionalised surfaces meet an important need for studying the multivalent interactions between carbohydrates and other biomolecules. Innovations in nanomaterials are revolutionising how these carbohydrate interfaces are studied and underscore their importance in the cosmos of biochemical interactions.