The stretch-inactivated channel, a vanilloid receptor variant, is expressed in small-diameter sensory neurons in the rat.
The stretch-inactivated channel, a vanilloid receptor variant, is expressed in small-diameter sensory neurons in the rat.
复制标题
拉伸失活通道是一种香草素受体变体，在大鼠的小直径感觉神经元中表达。
DOI：
10.1016/s0304-3940(00)01181-2
复制
发表时间：
2000
影响因子：
2.5
通讯作者：
Levine,JD
中科院分区：
文献类型：
--
作者：
Schumacher,MA;Jong,BE;Frey,SL;Sudanagunta,SP;Capra,NF;Levine,JD
暴露在高渗环境下会产生疼痛并激活小直径的感觉神经元。最近，香草酸受体变体和拉伸失活离子通道（SIC）被克隆，并被证明在细胞收缩响应中介导向内电流。由于其他香草受体先前已被证明介导伤害感觉，我们研究了SIC是否在感觉神经元中表达。利用逆转录聚合酶链反应和原位杂交技术，我们在背根和三叉神经节神经元中鉴定了SIC。此外，SIC被发现几乎只存在于小直径的感觉神经元中，其中包括伤害性神经元。由于SIC是由细胞收缩激活的，它可能参与高渗刺激产生的疼痛的调解。
Exposure to hypertonic conditions is known to produce pain and activate small-diameter sensory neurons. Recently, the vanilloid receptor variant and stretch-inactivated ion channel (SIC) was cloned and shown to mediate an inward current in response to cell shrinkage. Since other vanilloid receptors have been previously shown to mediate nociception, we investigated whether SIC is expressed in sensory neurons. Using reverse transcription-polymerase chain reaction and in situ hybridization techniques, we identified SIC in the neurons of dorsal root and trigeminal ganglia. Furthermore, SIC was found to be present almost exclusively in the small-diameter sensory neurons, which includes the nociceptive population. Since SIC is activated by cell shrinkage, it may participate in the mediation of pain produced by hypertonic stimuli.