Omega-3 fatty acids reduce post-operative risk of deep vein thrombosis and pulmonary embolism after surgery for elderly patients with proximal femoral fractures: a randomized placebo-controlled, double-blind clinical trial
Omega-3 fatty acids reduce post-operative risk of deep vein thrombosis and pulmonary embolism after surgery for elderly patients with proximal femoral fractures: a randomized placebo-controlled, double-blind clinical trial
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DOI：
10.1007/s00264-020-04610-0
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发表时间：
2020-05-22
影响因子：
2.7
通讯作者：
Wang, Zhijing
中科院分区：
文献类型：
--
作者：
Zheng, Xinying;Jia, Rufu;Wang, Zhijing
背景：由于缺乏合适的术后治疗方案，老年股骨近端骨折患者术后深静脉血栓形成和肺栓塞的风险增加。本研究旨在研究在上述临床环境中补充欧米茄-3脂肪酸的效果。方法选择507例老年股骨近端骨折患者（年龄> 60岁）。排除后，452名符合条件的患者被随机分配接受每日剂量为1000 mg的omega-3脂肪酸或安慰剂，术后30天口服给药。在干预结束时，比较两个研究组之间的肺栓塞、深静脉血栓形成和其他相关并发症的发生率。结果30天的omega-3脂肪酸干预显著降低了肺栓塞和深静脉血栓形成的发生率，包括导致死亡的事件。但其他相关并发症，如血肿清除，术后伤口出血，伤口感染与坦率脓，和其他出血事件，需要输血，不受影响后，ω-3脂肪酸消费。结论：老年股骨近端骨折患者术后每日补充omega-3脂肪酸可降低肺栓塞和症状性深静脉血栓形成的风险，且不会增加出血发作的风险。
Background Elderly patients with proximal femoral fractures face elevated risk of post-operative deep vein thrombosis and pulmonary embolism, due to the lack of suitable treatment plans after surgery and hospital discharge. This study aimed to investigate the effect of omega-3 fatty acid supplementation in the above-described clinical setting. Methods Five hundred and seven elderly patients (> 60 years of age) suffering from proximal femoral fractures were recruited. After exclusion, 452 eligible patients were assigned in a random manner to receive either omega-3 fatty acids at the daily dose of 1000 mg or placebo, via oral administration for a period of 30 days after surgery. At the end of intervention, the incidences of pulmonary embolism, deep vein thrombosis, and other related complications were compared between the two study groups. Results Incidences of pulmonary embolism as well as deep vein thrombosis, including events leading to fatality, were significantly reduced by the 30-day omega-3 fatty acid intervention. But other related complications, such as haematoma evacuation, post-operative wound bleed, wound infection with frank pus, and other bleed events that required transfusion, were not affected after omega-3 fatty acid consumption. Conclusion Daily supplementation of omega-3 fatty acids decreases the risk of pulmonary embolism as well as symptomatic deep vein thrombosis, after surgery among elderly patients with proximal femoral fractures, without causing elevated risk of bleeding episodes.