ALPHA-HEMOLYTIC STREPTOCOCCI - CLINICAL SIGNIFICANCE IN CANCER PATIENT
ALPHA-HEMOLYTIC STREPTOCOCCI - CLINICAL SIGNIFICANCE IN CANCER PATIENT
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DOI：
10.1002/mpo.2950040414
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发表时间：
1978-01-01
期刊：
影响因子：
--
通讯作者：
WITEBSKY, FG
中科院分区：
文献类型：
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作者：
PIZZO, PA;LADISCH, S;WITEBSKY, FG
在9年的时间里，27名癌症患者的29次败血症(12次多菌药)与溶血性链球菌有关。只有2名患者在脓毒症发生前进行了牙科操作，但每个患者都接受了化疗，75%的患者在感染时粒细胞减少。所有患者均未发生细菌性心内膜炎。与正常宿主不同的是，在拔牙或牙周手术后，可能会出现带有α-溶血性链球菌的暂时性细菌，癌症患者面临着更具临床意义的脓毒症的风险。这种风险可能与化疗引起的口腔粘膜炎和粒细胞减少有关，在发热的癌症患者中分离出α-溶血性链球菌不应被视为一种污染物。
.alpha.-Hemolytic streptococci were associated with 29 episodes of sepsis (12 polymicrobial) in 27 patients with cancer during a 9 yr period. Only 2 patients had dental manipulation prior to the onset of sepsis, but each received chemotherapy and 75% were granulocytopenic at the time of the infection. None of the patients developed bacterial endocarditis. Unlike the normal host in whom a transient bacteria with .alpha.-hemolytic Streptococci may occur following dental extraction or periodontal procedures, the cancer patient is at risk for more clinically significant sepsis. This risk is probably related to the presence of chemotherapy-induced oral mucusitis and granulocytopenia, and isolation of .alpha.-hemolytic streptococci in febrile cancer patients should not be dismissed as a contaminent.