Age-related extracellular to total body water volume ratio (ECV/TBW) -: Can it be used for "dry weight" determination in dialysis patients?: Application of multifrequency bioimpedance measurement
Age-related extracellular to total body water volume ratio (ECV/TBW) -: Can it be used for "dry weight" determination in dialysis patients?: Application of multifrequency bioimpedance measurement
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DOI：
10.1177/039139880202500803
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发表时间：
2002-08-01
影响因子：
1.7
通讯作者：
Sulková, S
中科院分区：
文献类型：
--
作者：
Lopot, F;Nejedly, B;Sulková, S
本文提出了一种基于细胞外体积（ECV）与全身水分（TBW）之比及其与年龄关系定量测定透析患者最佳干重的新方法。采用全身多频生物阻抗法测定ECV和TBW值。为了从生物阻抗数据中找到一个合适的个体水合状态标记，我们发现ECV/TBW比值与健康年龄之间存在显著相关性。假设透析患者的所有多余液体都完全储存在ECV中，并且其最佳干重状态下的TB in分布与同龄健康人的分布相对应，则透析前ECV/TBW可用于定量确定最佳干重和/或达到该重量的超滤。一组透析患者透析前和透析后的ECV/TBW的实际生物阻抗测量证实了上述两个假设，即超滤几乎完全来自细胞外，以及透析结束时ECV/TBW比率正常化。文献中也发现了随年龄增加的ECV/TBW值的支持证据。虽然建议的方法需要详细分析可能的干扰因素（参考ECV/TBW的种族“特异性”与健康年龄特征，透析患者的“生物”和“物理”年龄可能存在差异等），但文章发表在这个早期阶段，以便由不同的研究者对提出的新方法进行更广泛的测试。
The article suggests a novel method for quantitative determination of optimal dry weight in dialysis patient based on their extracellular volume (ECV) to total body water (TBW) ratio and its relation to age. Values of ECV and TBW are evaluated by means of whole body multifrequency bioimpedometry. In an effort to find a suitable marker of hydration status in an individual from bioimpedance data, significant correlation has been found between ECV/TBW ratio and age in health. Assuming that all excess fluid in dialysis patients is stored exclusively in ECV and that distribution of their TB IN at the state of optimal dry weight corresponds to that of a healthy person of the same age, the pre-dialysis ECV/TBW could be used for quantitative determination of optimal dry weight and/or of the ultrafiltration to reach this weight. Practical bioimpedance measurement of ECV/TBW in a group of dialysis patients both pre- and post-dialysis confirmed both above assumptions, i.e. nearly exclusively extracellular origin of ultrafiltration as well as normalisation of the ECV/TBW ratio towards the end of dialysis. Supporting evidence of increasing ECV/TBW value with age was also found in literature. Although the suggested method needs detailed analysis of possible disturbing factors (ethnic "specificity" of the reference ECV/TBW vs. age characteristics in health, possible difference in "biological" and "physical" age of dialysis patient and others), the article is published at this early stage to enable wider testing of the proposed novel method by different investigators.