Brain tissue volumes in the general elderly population - The Rotterdam Scan Study
Brain tissue volumes in the general elderly population - The Rotterdam Scan Study
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DOI：
10.1016/j.neurobiolaging.2006.12.012
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发表时间：
2008-06-01
影响因子：
4.2
通讯作者：
Breteler, Monique M. B.
中科院分区：
文献类型：
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作者：
Ikram, M. Arfan;Vrooman, Henri A.;Breteler, Monique M. B.
我们在鹿特丹扫描研究中调查了脑脊液（CSF）、灰质（GM）和白色物质（WM）的体积如何随年龄、性别、小血管疾病和心血管危险因素而变化。参与者（n = 490; 60-90岁）为非痴呆，5 1.0%患有高血压，4.9%患有糖尿病，17.8%目前吸烟，54.0%以前吸烟。我们将脑MR图像分割成GM、正常WM、白色病变（WML）和CSF。脑梗死通过视觉评定。以颅内容积的百分比表示。随着年龄的增长，男性和女性的总脑，正常WM和总WM的体积减少，GM保持不变，WML增加。排除梗死患者并没有改变这些结果。小血管病变负荷大者脑体积较小，尤其是正常WM体积。舒张压、糖尿病和目前吸烟也与较小的脑体积有关。在老年人中，较高的年龄，小血管疾病和心血管危险因素与较小的脑体积，特别是WM体积相关。(C)2007爱思唯尔公司All rights reserved.
We investigated how volumes of cerebrospinal fluid (CSF), grey matter (GM) and white matter (WM) varied with age, sex, small vessel disease and cardiovascular risk factors in the Rotterdam Scan Study. Participants (n = 490; 60-90 years) were non-demented and 5 1.0% had hypertension, 4.9% had diabetes mellitus, 17.8% were current smoker and 54.0% were former smoker. We segmented brain MR-images into GM, normal WM, white matter lesion (WML) and CSF. Brain infarcts were rated visually. Volumes were expressed as percentage of intra-cranial volume. With increasing age, volumes of total brain, normal WM and total WM decreased; that of GM remained unchanged; and that of WML increased, in both men and women. Excluding persons with infarcts did not alter these results. Persons with larger load of small vessel disease had smaller brain volume, especially normal WM volume. Diastolic blood pressure, diabetes mellitus and current smoking were also related to smaller brain volume. In the elderly, higher age, small vessel disease and cardiovascular risk factors are associated with smaller brain volume, especially WM volume. (C) 2007 Elsevier Inc. All rights reserved.