Paternal age and telomere length in twins: the germ stem cell selection paradigm.
Paternal age and telomere length in twins: the germ stem cell selection paradigm.
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DOI：
10.1111/acel.12334
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发表时间：
2015-08
期刊：
影响因子：
7.8
通讯作者：
Aviv A
中科院分区：
文献类型：
--
作者：
Hjelmborg JB;Dalgård C;Mangino M;Spector TD;Halekoh U;Möller S;Kimura M;Horvath K;Kark JD;Christensen K;Kyvik KO;Aviv A
端粒长度是一个高度遗传的性状，在年长父亲的后代中更长。这一令人困惑的特征被归因于老年男性精子中较长的端粒，这可能是一种“表观遗传”机制，通过这种机制，父亲的年龄在人类端粒长度调节中发挥作用。基于两个独立的（发现和复制）双胞胎的研究，包括889双胞胎对，我们发现增加的相似性白细胞端粒长度之间的双卵双胞胎的父亲，这是没有看到在单卵双胞胎。这种现象可能是由父系年龄依赖性生殖干细胞选择过程引起的，由此所选择的干细胞具有更长的端粒，相对于端粒长度更同质，并且具有抗衰老性。
Telomere length, a highly heritable trait, is longer in offspring of older fathers. This perplexing feature has been attributed to the longer telomeres in sperm of older men and it might be an ‘epigenetic’ mechanism through which paternal age plays a role in telomere length regulation in humans. Based on two independent (discovery and replication) twin studies, comprising 889 twin pairs, we show an increase in the resemblance of leukocyte telomere length between dizygotic twins of older fathers, which is not seen in monozygotic twins. This phenomenon might result from a paternal age-dependent germ stem cell selection process, whereby the selected stem cells have longer telomeres, are more homogenous with respect to telomere length, and share resistance to aging.