Oxymatrine protects against myocardial injury via inhibition of JAK2/STAT3 signaling in rat septic shock
Oxymatrine protects against myocardial injury via inhibition of JAK2/STAT3 signaling in rat septic shock
复制标题
氧化苦参碱通过抑制大鼠败血性休克中的 JAK2/STAT3 信号传导来防止心肌损伤
DOI：
10.3892/mmr.2013.1315
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发表时间：
2013-04-01
影响因子：
3.4
通讯作者：
Wang, Yin
中科院分区：
文献类型：
--
作者：
Zhang, Minghao;Wang, Xiuyu;Wang, Yin
氧化苦参碱（Oxymatrine，OMT）是从苦参中提取的一种生物碱，在传统中医药中用于治疗炎症性疾病和各种癌症。然而，OMT抗炎活性的细胞和分子机制仍然知之甚少。本研究通过抑制Janus激酶-信号转导子和转录激活子（JAK/STAT）信号通路的激活，探讨OMT对感染性休克大鼠心肌损伤的保护作用。OMT处理被发现显著抑制心肌组织中JAK 2和STAT 3的活化。它还减弱了促炎细胞因子的表达，包括白细胞介素-1 β和肿瘤坏死因子-α。此外，OMT具有抗炎作用，可改善心功能和心肌收缩力，防止感染性休克引起的心肌组织病理和超微结构损伤。结果表明，OMT通过抑制JAK 2/STAT 3信号通路对脓毒性休克诱导的心肌损伤具有显著的治疗潜力。
Oxymatrine (OMT), an alkaloid extracted from Sophora japonica (kushen), is used to treat inflammatory diseases and various types of cancer in traditional Chinese medicine. However, the cellular and molecular mechanisms underlying the anti-inflammatory activity of OMT remain poorly understood. The present study explored the protective effect of OMT on myocardial injury in rats with septic shock by inhibiting the activation of the janus kinase-signal transducer and activator of transcription (JAK/STAT) signaling pathway. OMT treatment was found to significantly inhibit the activation of JAK2 and STAT3 in myocardial tissue. It also attenuated the expression of pro-inflammatory cytokines, including interleukin-1 beta and tumor necrosis factor-alpha. In addition, OMT exhibited anti-inflammatory properties as heart function and myocardial contractility was improved and pathological and ultrastructural injury was prevented in myocardial tissue induced by septic shock. The results indicate that OMT exhibits substantial therapeutic potential for the treatment of septic shock-induced myocardial injury through inhibition of the JAK2/STAT3 signaling pathway.