LOCAL EXPRESSION OF ANTIINFLAMMATORY CYTOKINES IN CANCER
LOCAL EXPRESSION OF ANTIINFLAMMATORY CYTOKINES IN CANCER
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DOI：
10.1172/jci116256
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发表时间：
1993-03-01
影响因子：
15.9
通讯作者：
MOY, RL
中科院分区：
文献类型：
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作者：
YAMAMURA, M;MODLIN, RL;MOY, RL
为了表征局部细胞因子对癌症反应的性质，我们选择研究基底细胞癌（BCC）活检标本中的细胞因子模式。我们假设，与脂溢性角化病 (SK)（一种表皮良性生长）的模式相比，局部细胞因子产生的独特模式可能是 BCC（一种表皮肿瘤）的特征。我们通过对活检标本中的 mRNA 进行聚合酶链反应，分析了 BCC 与 SK 中的细胞因子 mRNA。编码IL-4、IL-5、IL-10和粒细胞巨噬细胞集落刺激因子的细胞因子的mRNA在BCC病变中强表达，而在SK病变中弱表达。相反，IL-2、IFN-γ和淋巴毒素 mRNA 在 SK 病变中强表达，而在 BCC 病变中弱表达。对恶性肿瘤 BCC 的反应以鼠 T(H)2 细胞的细胞因子特征为代表。这种细胞因子模式有利于体液免疫，同时抑制细胞介导的免疫反应。相比之下，对良性生长 SK 的反应以鼠 T(H)1 细胞特有的细胞因子为代表，有利于细胞介导的免疫反应。皮肤癌中独特细胞因子模式的发现为制定免疫干预策略提供了框架。
To characterize the nature of the local cytokine response to cancer, we chose to investigate cytokine patterns in biopsy specimens of basal cell carcinoma (BCC). We hypothesized that a distinct pattern of local cytokine production may be characteristic of BCC, a neoplasia of epidermis, in comparison to the pattern of seborrheic keratosis (SK), a benign growth of epidermis. We analyzed cytokine mRNAs in BCC versus SK by performing polymerase chain reaction on mRNA derived from biopsy specimens. The mRNAs encoding cytokines for IL-4, IL-5, IL-10, and granulocyte macrophage colony-stimulating factor were strongly expressed in BCC lesions and weakly expressed in SK lesions. Conversely, IL-2, IFN-gamma, and lymphotoxin mRNAs were strongly expressed in SK lesions and weakly expressed in BCC lesions. The response to malignancy, BCC, was typified by cytokines characteristic of murine T(H)2 cells. This cytokine pattern favors humoral immunity with concomitant immunosuppression of cell-mediated immune responses. In comparison, the response to the benign growth, SK, was typified by cytokines characteristic of murine T(H)1 cells that favor cell-mediated immune reactions. The findings of a distinct cytokine pattern in skin cancer provide a framework to develop strategies for immunologic intervention.