Age-related changes in the catecholamine content of peripheral organs in male and female F344 rats.
Age-related changes in the catecholamine content of peripheral organs in male and female F344 rats.
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雄性和雌性 F344 大鼠外周器官儿茶酚胺含量与年龄相关的变化。
DOI：
10.1093/geronj/36.3.280
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发表时间：
1981
期刊：
影响因子：
--
通讯作者：
McGaugh,JL
中科院分区：
文献类型：
--
作者：
MartinezJr,JL;Vasquez,BJ;Messing,RB;Jensen,RA;Liang,KC;McGaugh,JL
在接受交感神经支配的几个器官中，比较了雌雄两种F344大鼠的去甲肾上腺素水平。此外，还测定了年轻大鼠和老年大鼠肾上腺髓质的去甲肾上腺素和肾上腺素浓度。研究人员提出了一种基本原理，用于对外周器官中儿茶酚胺含量进行年龄相关的比较，这可以解释器官重量和体重的年龄相关变化。老龄雄性大鼠心廓内去甲肾上腺素浓度降低。相比之下，在老年雌性大鼠中，任何外周器官的儿茶酚胺含量都没有与年龄相关的变化。
Norepinephrine levels of old and young F344 rats of both sexes were compared in several organs that receive sympathetic innervation. In addition, both norepinephrine and epinephrine concentrations in the adrenal medulla of young and old rats were determined. A rationale was developed for making age-related comparisons of the catecholamine content in peripheral organs which accounted for age-related changes in organ weight and body weight. It was found that norepinephrine concentrations were decreased for old male rats in heart auricles. In contrast, in old female rats there were no age-related changes in the catecholamine content of any peripheral organ.