ET-1 released histamine from guinea pig pulmonary but not peritoneal mast cells.
ET-1 released histamine from guinea pig pulmonary but not peritoneal mast cells.
复制标题
ET-1从豚鼠肺部释放组胺，但不从腹膜肥大细胞释放组胺。
DOI：
10.1016/0006-291x(92)92331-q
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发表时间：
1992
影响因子：
3.1
通讯作者：
Hirata,F
中科院分区：
文献类型：
--
作者：
Uchida,Y;Ninomiya,H;Sakamoto,T;Lee,JY;Endo,T;Nomura,A;Hasegawa,S;Hirata,F
内皮素(ET)-1可引起豚鼠肺组织肥大细胞释放组胺，但不能引起豚鼠腹膜腔肥大细胞释放组胺。观察到的对ET-1反应的差异可归因于两个细胞之间ET-1结合位点的数量差异。组胺半最大释放和[125I]ET-1半结合所需的ET-1浓度分别约为0.05和0.08 nM。ET-1释放组胺的过程是钙依赖的，但不是细胞毒过程。这些观察结果表明，ET-1以受体依赖的方式诱导肥大细胞释放组胺。
Endothelin(ET)-1 triggered histamine release of mast cells from pulmonary tissue but not from the peritoneal cavity of guinea pigs. The observed difference in response to ET-1 was attributable to a quantitative difference in ET-1 binding sites between both cells. The concentrations of ET-1 required for half maximal release of histamine and half maximal binding of [125I]ET-1 were approximately 0.05 and 0.08 nM, respectively. The release of histamine by ET-1 was a Ca2+-dependent but not a cytotoxic process. These observations, taken together, suggest that ET-1 induces histamine release from mast cells in a receptor-dependent fashion.