Ex vivo evaluation of a multilayered sealant patch for watertight dural closure: cranial and spinal models.
Ex vivo evaluation of a multilayered sealant patch for watertight dural closure: cranial and spinal models.
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DOI：
10.1007/s10856-021-06552-4
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发表时间：
2021-07-23
期刊：
影响因子：
--
通讯作者：
van Doormaal TPC
中科院分区：
文献类型：
--
作者：
Kinaci A;van Thoor S;Redegeld S;Tooren M;van Doormaal TPC
脑脊液漏是颅脑和脊柱手术后常见的并发症。为了防止这种并发症并密封硬脑膜，我们开发了Liqoseal，这是一种硬脑膜密封剂贴片，包括防水聚酯聚氨酯层和粘合剂层，粘合剂层由聚（DL-丙交酯-co-ε-己内酯）共聚物和多臂N-羟基琥珀酰亚胺官能化聚乙二醇组成。我们使用计算机辅助模型和新鲜猪硬脑膜比较了Liqoseal、Adherus、Duraseal、Tachosil和Tisseel的急性爆破压和对生理条件的耐受性。Liqoseal在颅骨模型中的平均急性爆破压（145 ± 39 mmHg）高于Adherus（87 ± 47 mmHg）、Duraseal（51 ± 42 mmHg）和Tachosil（71 ± 16 mmHg）。在生理条件下，颅骨模型阻力测试结果显示，2/3的Liqoseal密封剂在72小时内保持硬脑膜附着，而Adherus和Duraseal为3/3，Tachosil为0/3。脊柱模型中Liqoseal的平均爆破压（233 ± 81 mmHg）高于Tachosil（123 ± 63 mmHg）和Tisseel（23 ± 16 mmHg）。在生理条件下，脊柱模型阻力测试结果显示，2/3种Liqoseal密封剂可维持硬脑膜附着72小时，而Adherus为3/3，Duraseal和Tachosil为0/3。这项新研究表明，Liqoseal能够在离体模型中对硬脑膜缺损实现牢固的水密密封。
Cerebrospinal fluid leakage is a frequent complication after cranial and spinal surgery. To prevent this complication and seal the dura watertight, we developed Liqoseal, a dural sealant patch comprising a watertight polyesterurethane layer and an adhesive layer consisting of poly(DL-lactide-co-ε-caprolactone) copolymer and multiarmed N-hydroxylsuccinimide functionalized polyethylene glycol. We compared acute burst pressure and resistance to physiological conditions for 72 h of Liqoseal, Adherus, Duraseal, Tachosil, and Tisseel using computer-assisted models and fresh porcine dura. The mean acute burst pressure of Liqoseal in the cranial model (145 ± 39 mmHg) was higher than that of Adherus (87 ± 47 mmHg), Duraseal (51 ± 42 mmHg) and Tachosil (71 ± 16 mmHg). Under physiological conditions, cranial model resistance test results showed that 2 of 3 Liqoseal sealants maintained dural attachment during 72 hours as opposed to 3 of 3 for Adherus and Duraseal and 0 of 3 for Tachosil. The mean burst pressure of Liqoseal in the spinal model (233 ± 81 mmHg) was higher than that of Tachosil (123 ± 63 mmHg) and Tisseel (23 ± 16 mmHg). Under physiological conditions, spinal model resistance test results showed that 2 of 3 Liqoseal sealants maintained dural attachment for 72 hours as opposed to 3 of 3 for Adherus and 0 of 3 for Duraseal and Tachosil. This novel study showed that Liqoseal is capable of achieving a strong watertight seal over a dural defect in ex vivo models.
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影响因子：
2
作者：
Ferroli, Paolo;Acerbi, Francesco;Broggi, Giovanni
通讯作者：
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2.2
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影响因子：
2.4
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