A short synthesis of the trisaccharide building block of the N-linked glycans
A short synthesis of the trisaccharide building block of the N-linked glycans
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DOI：
10.1016/s0040-4039(03)00102-3
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发表时间：
2003-02-24
影响因子：
1.8
通讯作者：
Crich, D
中科院分区：
文献类型：
--
作者：
Dudkin, VY;Crich, D
描述了在还原端含有p -叠氮基功能的n -连接糖蛋白的核心三糖的有效制备。在合成过程中，采用三酸酯介导的直接β -甘露糖基化反应形成β - d -man -(1—>4)- glcnac连锁；通过恶唑啉开环装置实现了端粒叠氮化物的安装。2003爱思唯尔科学有限公司版权所有。
An efficient preparation of the core trisaccharide of N-linked glycoproteins containing P-azido functionality at the reducing terminus is described. In the synthesis, triflate-mediated direct beta-mannosylation was employed for the formation of the beta-D-Man-(1-->4)-GlcNAc linkage; the anomeric azide installation was achieved through oxazoline ring opening. (C) 2003 Elsevier Science Ltd. All rights reserved.