An integrative model linking traumatization, cortisol dysregulation and posttraumatic stress disorder: Insight from recent hair cortisol findings
An integrative model linking traumatization, cortisol dysregulation and posttraumatic stress disorder: Insight from recent hair cortisol findings
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DOI：
10.1016/j.neubiorev.2016.07.015
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发表时间：
2016-10
影响因子：
8.2
通讯作者：
S. Steudte-Schmiedgen;C. Kirschbaum;N. Alexander;T. Stalder
中科院分区：
文献类型：
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作者：
S. Steudte-Schmiedgen;C. Kirschbaum;N. Alexander;T. Stalder
大量证据表明，创伤暴露、糖皮质激素皮质醇分泌改变和创伤后应激障碍（PTSD）的发展/维持之间存在联系，尽管研究结果存在一些不一致。进一步深入了解这一过程的复杂关系可能来自越来越多的研究，使用头发皮质醇分析，一种新的评估策略，假设回顾性地捕捉长期综合皮质醇分泌。在这里，我们评估的效用头发皮质醇分析作为一种方法在创伤/PTSD的研究和审查目前的研究结果在这种情况下。我们比较了头发皮质醇数据的创伤，皮质醇失调和创伤后应激障碍之间的复杂联系，对使用传统的皮质醇评估方法获得的主要结果。最后，我们将这些数据整合到一个模型中，该模型提出创伤会导致长期皮质醇输出的剂量和时间依赖性变化（最初的创伤后增加，随后的慢性衰减），并且这种失调可能部分介导创伤负荷之间的联系额外的创伤暴露后发生创伤后应激障碍的风险（“积木效应”）。
Abundant evidence suggests links between trauma exposure, altered secretion of the glucocorticoid cortisol and the development/maintenance of posttraumatic stress disorder (PTSD), albeit with some inconsistency in findings. Further insight into the complex relations underlying this process may be derived from an increasing number of studies using hair cortisol analysis, a novel assessment strategy assumed to retrospectively capture long-term integrated cortisol secretion. Here, we evaluate the utility of hair cortisol analysis as a method in trauma/PTSD research and review current findings in this context. We compare hair cortisol data on the complex links between trauma, cortisol dysregulation and PTSD against the main findings obtained using traditional cortisol assessment methods. Finally, we integrate these data into a model which proposes that traumatization leads to dose and time-dependent changes in long-term cortisol output (initial post-traumatic increase, subsequent chronic attenuation) and that such dysregulation may partly mediate the link between traumatic load and the risk of PTSD development upon additional trauma exposure (“building block effect”).