PLASMA DIGITALIS-LIKE ACTIVITY IN ESSENTIAL-HYPERTENSION OR END-STAGE RENAL-DISEASE
PLASMA DIGITALIS-LIKE ACTIVITY IN ESSENTIAL-HYPERTENSION OR END-STAGE RENAL-DISEASE
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DOI：
10.1161/01.hyp.8.7.632
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发表时间：
1986-07-01
期刊：
影响因子：
8.3
通讯作者：
MEYER, P
中科院分区：
文献类型：
--
作者：
DERAY, G;PERNOLLET, MG;MEYER, P
Plasma extracts from 119 subjects showed a digitalis-like activity, as evidenced by the ability of these extracts to inhibit ouabain binding to the Na+,K+ pump. High levels of the digitalis-like compound were found in 18 of 54 untreated hypertensive subjects, 7 of 21 normotensive subjects with a family history of hypertension, and 10 of 14 patients with end-stage renal failure. Dialysis significantly reduced the activity of this compound. These results suggest 1) that endogenous digitalis-like factor is not directly linked to hypertension but rather is related to sodium balance and 2) that it neither originates nor is activated by renal tissue, as it was present in four of six anephric patients.
