Obesity-related Polymorphisms and Their Associations With the Ability to Regulate Fat Oxidation in Obese Europeans: The NUGENOB Study
Obesity-related Polymorphisms and Their Associations With the Ability to Regulate Fat Oxidation in Obese Europeans: The NUGENOB Study
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DOI：
10.1038/oby.2009.377
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发表时间：
2010-07-01
期刊：
影响因子：
6.9
通讯作者：
Blaak, Ellen E.
中科院分区：
文献类型：
--
作者：
Corpeleijn, Eva;Petersen, Liselotte;Blaak, Ellen E.
肥胖和胰岛素抵抗都与低脂肪氧化率有关，这可能是由基因决定的。研究了26个脂肪氧化、胰岛素抵抗和肥胖候选基因中42个常见单核苷酸多态(SNPs)与肥胖(包括FTO)之间的关系。对来自欧洲8个中心的722名肥胖者(541名女性，181名男性)进行了空腹和高脂肪负荷后3h的能量消耗(EE)和脂肪氧化的测定。在调整中心和性别后，-178A&>C CD36(Rs2232169)(P=0.02)、-22510 C&>G SLC6A14(女性，rs2011162)(P=0.03)和T690S C&>G PCSK1(Rs6235)(P=0.02)与减少脂肪氧化有关，而17 C&>G SREBF1(17 C&>G)与空腹状态下脂肪氧化增加有关(P=0.01)。高脂肪负荷后增加脂肪氧化的能力在-174G&>C IL6受试者中增加(Rs1800795)(P=0.01)。效应大小在脂肪氧化方面的差异从1.1%到3.1%不等(以EE的百分比表示)。FTO rs9939609与脂肪氧化无关。同时，结果没有针对多次测试进行调整，因此没有一种关联被认为具有统计学意义。因此，这些结果只应被认为是关于特定基因多态对空腹和餐后脂肪氧化的影响的新假说。
Both obesity and insulin resistance have been related to low fat oxidation rates, which may be genetically determined. The association between variation in fat oxidation rates among obese subjects and genotype was studied for 42 common single-nucleotide polymorphisms (SNPs) in 26 candidate genes for fat oxidation, insulin resistance, and obesity, including FTO. Energy expenditure (EE) and fat oxidation were measured with indirect calorimetry during fasting and 3 h after a high fat load containing 95 energy% of fat (60% saturated fat, energy content 50% of estimated resting EE) in 722 obese subjects (541 women, 181 men) from 8 European centers. After adjustment for center and gender, -178 A>C CD36 (rs2232169) (P = 0.02), -22510 C>G SLC6A14 (women, rs2011162) (P = 0.03), and T690S C>G PCSK1 (rs6235) (P = 0.02) were related to a reduced fat oxidation, whereas 17 C>G SREBF1 (17 C>G) (P = 0.01) was related to increased fat oxidation in the fasting state. The ability to increase fat oxidation after a high fat load was increased in subjects with -174 G>C IL6 (rs1800795) (P = 0.01). Effect sizes range from 1.1 to 3.1% differences in fat oxidation (expressed as % of EE). FTO rs9939609 was not related to fat oxidation. At the same time, the results are not adjusted for multiple testing, thus none of the associations can be considered statistically significant. The results should therefore only be considered as leads to new hypotheses about effects of specific genetic polymorphisms on fasting and postprandial fat oxidation.